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    CycH Cyclin H [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CycHprovided by FlyBase
    Official Full Name
    Cyclin Hprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022936
    Locus tag
    Dmel_CG7405
    See related
    AllianceGenome:FB:FBgn0022936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142767_at; CCNH; CG7405; Dmel\CG7405
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CycH in Genome Data Viewer
    Location:
    78F3-78F3; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21821997..21823309)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21815097..21816409)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45958 Neighboring gene eagle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. Larochelle S, et al. EMBO J, 2001 Jul 16. PMID 11447116, Free PMC Article
    2. Xpd/Ercc2 regulates CAK activity and mitotic progression. Chen J, et al. Nature, 2003 Jul 10. PMID 12853965
    3. Secrets of a double agent: CDK7 in cell-cycle control and transcription. Fisher RP. J Cell Sci, 2005 Nov 15. PMID 16280550
    4. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase. Nag RN, et al. Development, 2018 Jan 25. PMID 29361561, Free PMC Article
    5. Identification of a cyclin subunit required for the function of Drosophila P-TEFb. Peng J, et al. J Biol Chem, 1998 May 29. PMID 9593731

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of carboxy-terminal domain protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIK complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin H
    Names
    CG7405-PA
    CycH-PA
    CyclinH
    cyclin-H

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21821997..21823309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079483.3 → NP_524207.1  cyclin H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76513, Q32KG2
      Related
      FBpp0078093
      Conserved Domains (3) summary
      TIGR00569
      Location:2 → 307
      ccl1; cyclin ccl1
      cd00043
      Location:63 → 127
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam16899
      Location:159 → 257
      Cyclin_C_2; Cyclin C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17144 O17144
    O76513 O76513

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