foi fear-of-intimacy [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: foiprovided by FlyBase
Official Full Name: fear-of-intimacyprovided by FlyBase
Primary source: FLYBASE:FBgn0024236
Locus tag: Dmel_CG6817
See related: AllianceGenome:FB:FBgn0024236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg6817; CG6817; dFOI; Dmel\CG6817; dZipFOI; dZIPfoi; dZIPFoi; Foi; FOI; kas; l(3)j8E8; l(3)neo13
Summary: Enables zinc ion transmembrane transporter activity. Involved in several processes, including branch fusion, open tracheal system; gonad development; and intracellular zinc ion homeostasis. Located in basolateral plasma membrane and cell surface. Is expressed in adult head. Orthologous to several human genes including SLC39A6 (solute carrier family 39 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8525244..8534503)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8518344..8527603)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila.
Title: Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila.
ZIP transporter Fear-of-intimacy (Foi) is necessary for the formation of Drosophila muscles.
Title: Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis.
in vivo structure-function analysis of FOI that strongly indicates that zinc transport activity of FOI is essential for gonad development
Title: Zinc transport activity of Fear of Intimacy is essential for proper gonad morphogenesis and DE-cadherin expression.
cell-surface protein required in the mesoderm for gonad morphogenesis
Title: fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in gonad development	TAS Traceable Author Statement more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed