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    TAAR9 trace amine associated receptor 9 [ Homo sapiens (human) ]

    Gene ID: 134860, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAAR9provided by HGNC
    Official Full Name
    trace amine associated receptor 9provided by HGNC
    Primary source
    HGNC:HGNC:20977
    See related
    Ensembl:ENSG00000237110 MIM:608282; AllianceGenome:HGNC:20977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TA3; TAR3; TAR9; TRAR3
    Summary
    TAAR9 is a member of a large family of rhodopsin G protein-coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Jul 2005]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Orthologs
    all
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    Genomic context

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    See TAAR9 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132538277..132539336)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133733231..133734290)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132859416..132860475)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene syntaxin 7 Neighboring gene Sharpr-MPRA regulatory region 15532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25071 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:132833503-132834004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25072 Neighboring gene ribosomal protein L21 pseudogene 66 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:132848222-132849421 Neighboring gene trace amine associated receptor 8 Neighboring gene trace amine associated receptor 7, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of a null mutation in a human trace amine receptor gene. Vanti WB, et al. Genomics, 2003 Nov. PMID 14559210
    2. Correlation of a set of gene variants, life events and personality features on adult ADHD severity. Müller DJ, et al. J Psychiatr Res, 2010 Jul. PMID 20006992
    3. A second class of chemosensory receptors in the olfactory epithelium. Liberles SD, et al. Nature, 2006 Aug 10. PMID 16878137
    4. Trace amines: identification of a family of mammalian G protein-coupled receptors. Borowsky B, et al. Proc Natl Acad Sci U S A, 2001 Jul 31. PMID 11459929, Free PMC Article
    5. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Lindemann L, et al. Genomics, 2005 Mar. PMID 15718104

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables trace-amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trace-amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory perception of smell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    trace amine-associated receptor 9
    Names
    trace amine receptor 3
    trace amine receptor 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175057.4 → NP_778227.3  trace amine-associated receptor 9

      See identical proteins and their annotated locations for NP_778227.3

      Status: VALIDATED

      Source sequence(s)
      AL513524, KF459634
      Consensus CDS
      CCDS75520.1
      UniProtKB/Swiss-Prot
      Q96RI9
      Related
      ENSP00000424607.2, ENST00000434551.3
      Conserved Domains (2) summary
      pfam00001
      Location:49 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:43 → 271
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      132538277..132539336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133733231..133734290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RI9.1 GenPept UniProtKB/Swiss-Prot:Q96RI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous