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    TCEANC transcription elongation factor A N-terminal and central domain containing [ Homo sapiens (human) ]

    Gene ID: 170082, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TCEANCprovided by HGNC
    Official Full Name
    transcription elongation factor A N-terminal and central domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:28277
    See related
    Ensembl:ENSG00000176896 MIM:301084; AllianceGenome:HGNC:28277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCEANC1
    Summary
    Predicted to be involved in DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 1.6), thyroid (RPKM 1.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCEANC in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (13653141..13665409)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (13234528..13246800)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (13671260..13683528)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene EGF like domain multiple 6 Neighboring gene microRNA 6086 Neighboring gene RN7SK pseudogene 20 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:13630114-13630666 Neighboring gene NANOG hESC enhancer GRCh37_chrX:13638269-13638787 Neighboring gene uncharacterized LOC107985657 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13671061-13671372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29442 Neighboring gene uncharacterized LOC107985656 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:13687079-13688278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20668 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13710181-13710377 Neighboring gene RAB9A, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. Satoh J, et al. J Neurosci Methods, 2006 Apr 15. PMID 16260042
    2. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. Teixeira FR, et al. J Biol Chem, 2013 Sep 27. PMID 23940030, Free PMC Article
    3. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article
    4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Hill SJ, et al. Genes Dev, 2014 Sep 1. PMID 25184681, Free PMC Article
    5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC17403

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A N-terminal and central domain-containing protein
    Names
    TFIIS central domain-containing protein 1
    TFS2-M domain-containing protein 1
    transcription elongation factor A (SII) N-terminal and central domain containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297563.2 → NP_001284492.1  transcription elongation factor A N-terminal and central domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001284492.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional exon in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC079383, AK291271, BC020095
      Consensus CDS
      CCDS75954.1
      UniProtKB/Swiss-Prot
      A6NI06, B2RDM3, Q8N8B7
      UniProtKB/TrEMBL
      A0A8Q3SID2
      Related
      ENSP00000512421.1, ENST00000696128.1
      Conserved Domains (4) summary
      TIGR01385
      Location:6 → 343
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:172 → 278
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
      pfam08711
      Location:29 → 78
      Med26; TFIIS helical bundle-like domain
      cl02609
      Location:289 → 343
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    2. NM_001297564.2 → NP_001284493.1  transcription elongation factor A N-terminal and central domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001284493.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR and coding region which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC079383, AK315599, BC020095
      Consensus CDS
      CCDS75954.1
      UniProtKB/Swiss-Prot
      A6NI06, B2RDM3, Q8N8B7
      UniProtKB/TrEMBL
      A0A8Q3SID2
      Related
      ENSP00000369974.1, ENST00000380600.2
      Conserved Domains (4) summary
      TIGR01385
      Location:6 → 343
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:172 → 278
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
      pfam08711
      Location:29 → 78
      Med26; TFIIS helical bundle-like domain
      cl02609
      Location:289 → 343
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    3. NM_152634.4 → NP_689847.2  transcription elongation factor A N-terminal and central domain-containing protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC079383, AK294465, BC020095
      Consensus CDS
      CCDS48081.1
      UniProtKB/TrEMBL
      B4DG85
      Related
      ENSP00000440038.2, ENST00000544987.3
      Conserved Domains (4) summary
      TIGR01385
      Location:36 → 373
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:202 → 308
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
      pfam08711
      Location:59 → 108
      Med26; TFIIS helical bundle-like domain
      cl02609
      Location:319 → 373
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      13653141..13665409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029316.2 → XP_016884805.1  transcription elongation factor A N-terminal and central domain-containing protein isoform X1

      UniProtKB/TrEMBL
      B4DG85
      Conserved Domains (4) summary
      TIGR01385
      Location:36 → 373
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:202 → 308
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
      pfam08711
      Location:59 → 108
      Med26; TFIIS helical bundle-like domain
      cl02609
      Location:319 → 373
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      13234528..13246800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326596.1 → XP_054182571.1  transcription elongation factor A N-terminal and central domain-containing protein isoform X1

      UniProtKB/TrEMBL
      B4DG85
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8B7.2 GenPept UniProtKB/Swiss-Prot:Q8N8B7

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