SPARC secreted protein acidic and cysteine rich [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPARCprovided by HGNC
Official Full Name: secreted protein acidic and cysteine richprovided by HGNC
Primary source: HGNC:HGNC:11219
See related: Ensembl:ENSG00000113140 MIM:182120; AllianceGenome:HGNC:11219
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ON; ONT; OI17; BM-40
Summary: This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]
Expression: Broad expression in fat (RPKM 883.5), placenta (RPKM 823.4) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q33.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (151661096..151686915, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (152200073..152225896, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (151040657..151066476, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of SPARC Expression Enhances the Fusion of BeWo Choriocarcinoma Cells.
Title: Downregulation of SPARC Expression Enhances the Fusion of BeWo Choriocarcinoma Cells.
Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet.
Title: Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet.
The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
Title: The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
Osteonectin (SPARC) prognostic value in prostate cancer.
Title: Osteonectin (SPARC) prognostic value in prostate cancer.
Immunohistochemical expression of SPARC in odontogenic keratocysts: a comparative study with other odontogenic cysts.
Title: Immunohistochemical expression of SPARC in odontogenic keratocysts: a comparative study with other odontogenic cysts.
The association of SPARC with hypertension and its function in endothelial-dependent relaxation.
Title: The association of SPARC with hypertension and its function in endothelial-dependent relaxation.
Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein-Barr virus: A poor prognostic marker.
Title: Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein-Barr virus: A poor prognostic marker.
Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection.
Title: Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection.
Novel pathogenic variants in SPARC as cause of osteogenesis imperfecta: Two case reports.
Title: Novel pathogenic variants in SPARC as cause of osteogenesis imperfecta: Two case reports.
Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.
Title: Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.

Submit: New GeneRIF Correction See all GeneRIFs (308)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Osteogenesis imperfecta type 17 MedGen: C4225301 OMIM: 616507 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A007I34 (e-PCR)
- UniSTS:8192

D5S2416 (e-PCR)
- UniSTS:44807

SHGC-84435 (e-PCR)
- UniSTS:104737

RH68620 (e-PCR)
- UniSTS:52073

RH41219 (e-PCR)
- UniSTS:92802

234 (e-PCR), detects polymorphism
- UniSTS:34189

GDB:201800 (e-PCR)
- UniSTS:156061

RH71413 (e-PCR)
- UniSTS:75456

D5S2386 (e-PCR)
- UniSTS:32201

RH65614 (e-PCR)
- UniSTS:53202

RH47515 (e-PCR)
- UniSTS:89827

STS-J03040 (e-PCR)
- UniSTS:3559

SPARC_1369 (e-PCR)
- UniSTS:462567

GDB:294200 (e-PCR)
- UniSTS:156392

D5S444E (e-PCR)
- UniSTS:6399

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in semicircular canal morphogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
NOT located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle lumen	TAS Traceable Author Statement more info
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
NOT located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
NOT located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in platelet alpha granule	IDA Inferred from Direct Assay more info	PubMed
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info
located_in platelet alpha granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SPARC

Names: basement-membrane protein 40; secreted protein, acidic, cysteine-rich (osteonectin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042174.1 RefSeqGene

Range

5140..30959

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001309443.2 → NP_001296372.1 SPARC isoform 2 precursor

See identical proteins and their annotated locations for NP_001296372.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AL541830, BC072457, BI602719, BQ018477

UniProtKB/TrEMBL

B2RDL6

Conserved Domains (2) summary

cd01328
Location:70 → 151

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

cd16231
Location:154 → 293

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins
NM_001309444.2 → NP_001296373.1 SPARC isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a longer and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC011374, AL540785, BC072457, BI602719, BQ018477

UniProtKB/TrEMBL

B2RDL6

Conserved Domains (3) summary

cd00252
Location:154 → 290

SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

cd01328
Location:71 → 152

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

pfam10591
Location:153 → 287

SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
NM_003118.4 → NP_003109.1 SPARC isoform 1 precursor

See identical proteins and their annotated locations for NP_003109.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the predominant isoform (1).

Source sequence(s)

BC072457, BQ018477

Consensus CDS

CCDS4318.1

UniProtKB/Swiss-Prot

D3DQH9, P09486, Q6IBK4

UniProtKB/TrEMBL

B2RDL6

Related

ENSP00000231061.4, ENST00000231061.9

Conserved Domains (2) summary

cd01328
Location:71 → 152

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

cd16231
Location:155 → 294

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins