SRGN serglycin [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRGNprovided by HGNC
Official Full Name: serglycinprovided by HGNC
Primary source: HGNC:HGNC:9361
See related: Ensembl:ENSG00000122862 MIM:177040; AllianceGenome:HGNC:9361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PPG; PRG; PRG1
Summary: This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
Expression: Biased expression in bone marrow (RPKM 1650.2), appendix (RPKM 289.1) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (69087603..69104811)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (69925937..69973238)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (70847359..70864567)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum.
Title: miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum.
Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.
Title: Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.
SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.
Title: SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.
Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.
Title: Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.
Clinical Significance of Serglycin Expression in Human Breast Cancer Patients.
Title: Clinical Significance of Serglycin Expression in Human Breast Cancer Patients.
The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a beta-catenin-dependent manner.
Title: The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.
Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study.
Title: Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study.
The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy.
Title: The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy.
SRGN, a new identified shear-stress-responsive gene in endothelial cells.
Title: SRGN, a new identified shear-stress-responsive gene in endothelial cells.
SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression.
Title: SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S2147 (e-PCR)
- UniSTS:21773

RH45489 (e-PCR)
- UniSTS:3086

SHGC-132036 (e-PCR)
- UniSTS:173883

WI-17483 (e-PCR)
- UniSTS:61244

STS-X17042 (e-PCR)
- UniSTS:32610

GDB:193871 (e-PCR)
- UniSTS:155779

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell secretory granule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in granzyme-mediated programmed cell death signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of granzyme B location in T cell secretory granule	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of protease location in mast cell secretory granule	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell secretory granule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in secretory granule organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytolytic granule	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in mast cell granule	ISS Inferred from Sequence or Structural Similarity more info
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serglycin

Names: hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; hematopoietic proteoglycan core protein; p.PG; platelet proteoglycan core protein; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan core peptide; secretory granule proteoglycan core protein; serglycin proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001321053.2 → NP_001307982.1 serglycin isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode isoform 1.

Source sequence(s)

AL442635, BC015516, BP363056

Consensus CDS

CCDS7285.1

UniProtKB/Swiss-Prot

B2R4L7, P10124, Q5VW06

Conserved Domains (1) summary

pfam04360
Location:3 → 150

Serglycin
NM_001321054.1 → NP_001307983.1 serglycin isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate internal exon in the coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.

Source sequence(s)

AI347627, AL442635, BC015516, BP335278, BQ051861, CD677686

UniProtKB/Swiss-Prot

P10124

Conserved Domains (1) summary

pfam04360
Location:22 → 94

Serglycin; Serglycin
NM_002727.4 → NP_002718.2 serglycin isoform 1 precursor

See identical proteins and their annotated locations for NP_002718.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an exon in the 5' UTR compared to variant 2. Both variants 1 and 3 encode isoform 1.

Source sequence(s)

BC015516, BG057351, BG548665, CA308463, CB110512

Consensus CDS

CCDS7285.1

UniProtKB/Swiss-Prot

B2R4L7, P10124, Q5VW06

Related

ENSP00000242465.3, ENST00000242465.4

Conserved Domains (1) summary

pfam04360
Location:3 → 150

Serglycin