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    DRG2 developmentally regulated GTP binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 1819, updated on 27-Nov-2024

    Summary

    Official Symbol
    DRG2provided by HGNC
    Official Full Name
    developmentally regulated GTP binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:3030
    See related
    Ensembl:ENSG00000108591 MIM:602986; AllianceGenome:HGNC:3030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DRG2 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18087948..18107969)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18034778..18054782)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17991262..18011283)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene Sharpr-MPRA regulatory region 6800 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17925691-17925854 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11823 Neighboring gene GID complex subunit 4 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991145-17991646 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991647-17992146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18010366-18011013 Neighboring gene uncharacterized LOC105371566 Neighboring gene myosin XVA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18038431-18039424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18039425-18040418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18045565-18046530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18046531-18047495 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124903944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18053522-18054022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18056260-18056783

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    developmentally-regulated GTP-binding protein 2
    Names
    TRAFAC GTPase DRG2
    translation factor GTPase DRG2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330144.2NP_001317073.1  developmentally-regulated GTP-binding protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC087164
      Consensus CDS
      CCDS82082.1
      UniProtKB/TrEMBL
      A8MZF9
      Related
      ENSP00000379076.4, ENST00000395726.8
      Conserved Domains (4) summary
      cd01896
      Location:63295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1331
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl00155
      Location:289331
      UBQ; Ubiquitin-like proteins
      cl21455
      Location:3119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001388.5NP_001379.1  developmentally-regulated GTP-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001379.1

      Status: REVIEWED

      Source sequence(s)
      BC000493, DA602486, X80754
      Consensus CDS
      CCDS11191.1
      UniProtKB/Swiss-Prot
      B2R8G5, P55039, Q53Y50, Q9BWB2
      Related
      ENSP00000225729.3, ENST00000225729.8
      Conserved Domains (4) summary
      cd01666
      Location:289363
      TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
      cd01896
      Location:63295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1364
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:3119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      18087948..18107969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256499.4XP_005256556.1  developmentally-regulated GTP-binding protein 2 isoform X1

      Conserved Domains (4) summary
      cd01666
      Location:289384
      TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
      cd01896
      Location:63295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1385
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:3119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_011523704.3XP_011522006.1  developmentally-regulated GTP-binding protein 2 isoform X2

      Conserved Domains (4) summary
      cd01896
      Location:63295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1352
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl00155
      Location:289352
      UBQ; Ubiquitin-like proteins
      cl21455
      Location:3119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_005256500.3XP_005256557.1  developmentally-regulated GTP-binding protein 2 isoform X3

      Conserved Domains (2) summary
      cd01666
      Location:208303
      TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
      cd01896
      Location:1214
      DRG; Developmentally Regulated GTP-binding protein (DRG)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      18034778..18054782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315305.1XP_054171280.1  developmentally-regulated GTP-binding protein 2 isoform X1

    2. XM_054315306.1XP_054171281.1  developmentally-regulated GTP-binding protein 2 isoform X2

    3. XM_054315307.1XP_054171282.1  developmentally-regulated GTP-binding protein 2 isoform X3