PTGER4 prostaglandin E receptor 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTGER4provided by HGNC
Official Full Name: prostaglandin E receptor 4provided by HGNC
Primary source: HGNC:HGNC:9596
See related: Ensembl:ENSG00000171522 MIM:601586; AllianceGenome:HGNC:9596
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EP4; EP4R
Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Expression: Broad expression in bone marrow (RPKM 30.5), colon (RPKM 12.1) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p13.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (40679915..40746800)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (40936331..41003197)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (40680017..40693837)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils.
Title: Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils.
Association between vertebral endplate defects and patient-reported symptoms: an immunohistochemical study investigating the COX-2/PGE-2/EP-4 axis.
Title: Association between vertebral endplate defects and patient-reported symptoms: an immunohistochemical study investigating the COX-2/PGE-2/EP-4 axis.
EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.
Title: EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.
Complementary roles of EP2 and EP4 receptors in malignant glioma.
Title: Complementary roles of EP2 and EP4 receptors in malignant glioma.
Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer.
Title: Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer.
The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway.
Title: The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway.
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells.
Title: PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells.
Nanomolar EP4 receptor potency and expression of eicosanoid-related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia.
Title: Nanomolar EP4 receptor potency and expression of eicosanoid-related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia.
Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy.
Title: Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy.
CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression.
Title: CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression.

Submit: New GeneRIF Correction See all GeneRIFs (149)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Systematic association mapping identifies NELL1 as a novel IBD disease gene. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	Prostaglandin E2 downregulates HIV-1 CA/p24 production through the EP2 and EP4 receptors	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PTGER4_1066 (e-PCR)
- UniSTS:277621

D5S1920 (e-PCR)
- UniSTS:58504

SHGC-64757 (e-PCR)
- UniSTS:184204

STS-L25124 (e-PCR)
- UniSTS:20119

STS-N92884 (e-PCR)
- UniSTS:56223

PMC311006P6 (e-PCR)
- UniSTS:272833

STS-N31927 (e-PCR)
- UniSTS:44493

NoName (e-PCR)
- UniSTS:484328

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in bone development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to prostaglandin E stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of eosinophil extravasation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of integrin activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nematode	IEA Inferred from Electronic Annotation more info
involved_in response to prostaglandin E	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP4 subtype

Names: PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostanoid EP4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047000.1 RefSeqGene

Range

5418..19238

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000958.3 → NP_000949.1 prostaglandin E2 receptor EP4 subtype

See identical proteins and their annotated locations for NP_000949.1

Status: REVIEWED

Source sequence(s)

AC093264, BC027934, BM312677, BQ029720, CD000197, L28175

Consensus CDS

CCDS3930.1

UniProtKB/Swiss-Prot

P35408, Q3MJ87

Related

ENSP00000302846.3, ENST00000302472.4

Conserved Domains (1) summary

cd15142
Location:18 → 341

7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

40679915..40746800

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017009659.3 → XP_016865148.1 prostaglandin E2 receptor EP4 subtype isoform X3

Conserved Domains (2) summary

pfam00001
Location:34 → 222

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 216

7tm_4; Olfactory receptor
XM_047417415.1 → XP_047273371.1 prostaglandin E2 receptor EP4 subtype isoform X3
XM_047417413.1 → XP_047273369.1 prostaglandin E2 receptor EP4 subtype isoform X1
XM_047417414.1 → XP_047273370.1 prostaglandin E2 receptor EP4 subtype isoform X2
XM_047417416.1 → XP_047273372.1 prostaglandin E2 receptor EP4 subtype isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

40936331..41003197

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352960.1 → XP_054208935.1 prostaglandin E2 receptor EP4 subtype isoform X3
XM_054352961.1 → XP_054208936.1 prostaglandin E2 receptor EP4 subtype isoform X3
XM_054352958.1 → XP_054208933.1 prostaglandin E2 receptor EP4 subtype isoform X1
XM_054352959.1 → XP_054208934.1 prostaglandin E2 receptor EP4 subtype isoform X2
XM_054352962.1 → XP_054208937.1 prostaglandin E2 receptor EP4 subtype isoform X4