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    PTK7 protein tyrosine kinase 7 (inactive) [ Homo sapiens (human) ]

    Gene ID: 5754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTK7provided by HGNC
    Official Full Name
    protein tyrosine kinase 7 (inactive)provided by HGNC
    Primary source
    HGNC:HGNC:9618
    See related
    Ensembl:ENSG00000112655 MIM:601890; AllianceGenome:HGNC:9618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCK4; CCK-4
    Summary
    This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in endometrium (RPKM 43.5), ovary (RPKM 31.2) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTK7 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43076314..43161715)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42905060..42990493)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43044052..43129453)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43027385-43028336 Neighboring gene Sharpr-MPRA regulatory region 10128 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43038920-43039420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43043187-43043710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17218 Neighboring gene kinesin light chain 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43049243-43049446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43050481-43051047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43051048-43051613 Neighboring gene KLC4 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43057365-43057958 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:43057959-43058553 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43058554-43059147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43086921-43087840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43087841-43088760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43099803-43100304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43100305-43100804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24592 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43138211-43138940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17219 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43139967-43140935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43145601-43146102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43146103-43146602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17221 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:43154118-43155317 Neighboring gene serum response factor Neighboring gene cullin 9 Neighboring gene MPRA-validated peak5812 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43190560-43191097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma. Liu K, et al. World J Surg Oncol, 2017 May 25. PMID 28545451, Free PMC Article
    2. PTK7 protein is decreased in epithelial ovarian carcinomas with poor prognosis. Wang H, et al. Int J Clin Exp Pathol, 2014. PMID 25550828, Free PMC Article
    3. Protein tyrosine kinase 7: a hepatocellular carcinoma-related gene detected by triple-combination array. Hishida M, et al. J Surg Res, 2015 May 15. PMID 25796105
    4. Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer. Lhoumeau AC, et al. PLoS One, 2015. PMID 25962058, Free PMC Article
    5. Role of the planar cell polarity gene Protein tyrosine kinase 7 in neural tube defects in humans. Wang M, et al. Birth Defects Res A Clin Mol Teratol, 2015 Dec. PMID 26368655

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXP4-mediated induction of PTK7 activates the Wnt/beta-catenin pathway and promotes ovarian cancer development.
      Title: FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development.
    2. Elucidating the Functional Mechanism of PTK7 in Cancer Development through Spatial Assembly Analysis Using Super Resolution Imaging.
      Title: Elucidating the Functional Mechanism of PTK7 in Cancer Development through Spatial Assembly Analysis Using Super Resolution Imaging.
    3. Knockdown of PTK7 Reduces the Oncogenic Potential of Breast Cancer Cells by Impeding Receptor Tyrosine Kinase Signaling.
      Title: Knockdown of PTK7 Reduces the Oncogenic Potential of Breast Cancer Cells by Impeding Receptor Tyrosine Kinase Signaling.
    4. Proteomic and Phosphoproteomic Analyses Reveal the Oncogenic Role of PTK7-NDRG1 Axis in Non-small-cell Lung Cancer Cell Resistance to AZD9291.
      Title: Proteomic and Phosphoproteomic Analyses Reveal the Oncogenic Role of PTK7-NDRG1 Axis in Non-small-cell Lung Cancer Cell Resistance to AZD9291.
    5. Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves.
      Title: Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves.
    6. High expression of protein tyrosine kinase 7 in oral squamous cell carcinoma: Clinicopathological correlation and prognosis relevance.
      Title: High expression of protein tyrosine kinase 7 in oral squamous cell carcinoma: Clinicopathological correlation and prognosis relevance.
    7. PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells.
      Title: PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells.
    8. Whole-Exome Sequencing Identifies a Novel Germline Variant in PTK7 Gene in Familial Colorectal Cancer.
      Title: Whole-Exome Sequencing Identifies a Novel Germline Variant in PTK7 Gene in Familial Colorectal Cancer.
    9. The Mutational Landscape of PTK7 in Congenital Scoliosis and Adolescent Idiopathic Scoliosis.
      Title: The Mutational Landscape of PTK7 in Congenital Scoliosis and Adolescent Idiopathic Scoliosis.
    10. LncRNA-MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR-205-PTK7 pathway.
      Title: LncRNA-MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR-205-PTK7 pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (57)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables axon guidance receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables coreceptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axis elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cochlea morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in convergent extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coronary vasculature development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of planar polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lung-associated mesenchyme development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion HDA PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inactive tyrosine-protein kinase 7
    Names
    PTK7 protein tyrosine kinase 7
    colon carcinoma kinase 4
    pseudo tyrosine kinase receptor 7
    tyrosine-protein kinase-like 7
    NP_001257327.1
    NP_002812.2
    NP_690619.1
    NP_690620.1
    NP_690621.1
    XP_011513067.1
    XP_011513068.1
    XP_047275113.1
    XP_054212039.1
    XP_054212040.1
    XP_054212041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270398.2 → NP_001257327.1  inactive tyrosine-protein kinase 7 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant PTK7-1. The encoded isoform (e) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AI140260, AK291016, AK296953, BQ881986, CN266652
      Consensus CDS
      CCDS59021.1
      UniProtKB/Swiss-Prot
      Q13308
      Related
      ENSP00000418754.1, ENST00000481273.5
      Conserved Domains (9) summary
      cd05046
      Location:798 → 1071
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd00096
      Location:250 → 310
      Ig; Immunoglobulin domain
      cd05760
      Location:154 → 230
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:613 → 677
      IGc2; Immunoglobulin C-2 Type
      smart00221
      Location:809 → 1069
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:348 → 416
      IG; Immunoglobulin
      smart00410
      Location:606 → 689
      IG_like; Immunoglobulin like
      pfam07679
      Location:420 → 506
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:422 → 506
      Ig; Immunoglobulin domain

    2. NM_002821.5 → NP_002812.2  inactive tyrosine-protein kinase 7 isoform a precursor

      See identical proteins and their annotated locations for NP_002812.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (PTK7-1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AF531868, AI140260, AK291016, CA389442
      Consensus CDS
      CCDS4884.1
      UniProtKB/Swiss-Prot
      A8K974, B7Z477, E9PFZ5, Q13308, Q13417, Q5T650, Q6IQ54, Q8NFA5, Q8NFA6, Q8NFA7, Q8NFA8
      Related
      ENSP00000230419.4, ENST00000230419.9
      Conserved Domains (8) summary
      cd05046
      Location:790 → 1063
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd00096
      Location:242 → 302
      Ig; Immunoglobulin domain
      cd05760
      Location:146 → 222
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:605 → 669
      IGc2; Immunoglobulin C-2 Type
      smart00221
      Location:801 → 1061
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:598 → 681
      IG_like; Immunoglobulin like
      pfam07679
      Location:412 → 498
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:414 → 498
      Ig; Immunoglobulin domain

    3. NM_152880.4 → NP_690619.1  inactive tyrosine-protein kinase 7 isoform b precursor

      See identical proteins and their annotated locations for NP_690619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (PTK7-2) lacks an exon in the coding region, but maintains the reading frame, compared to variant PTK7-1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AF531869, AI140260, AK291016, CA389442
      Consensus CDS
      CCDS4885.1
      UniProtKB/Swiss-Prot
      Q13308
      Related
      ENSP00000325992.4, ENST00000345201.6
      Conserved Domains (9) summary
      cd05046
      Location:750 → 1023
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd00096
      Location:242 → 302
      Ig; Immunoglobulin domain
      cd05760
      Location:146 → 222
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:565 → 629
      IGc2; Immunoglobulin C-2 Type
      smart00221
      Location:761 → 1021
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:231 → 301
      IG; Immunoglobulin
      smart00410
      Location:558 → 641
      IG_like; Immunoglobulin like
      pfam07679
      Location:412 → 498
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:414 → 498
      Ig; Immunoglobulin domain

    4. NM_152881.4 → NP_690620.1  inactive tyrosine-protein kinase 7 isoform c precursor

      See identical proteins and their annotated locations for NP_690620.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (PTK7-3) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant PTK7-1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AF531870, AI140260, AK291016, CA389442
      Consensus CDS
      CCDS4886.1
      UniProtKB/Swiss-Prot
      Q13308
      Related
      ENSP00000325462.4, ENST00000349241.6
      Conserved Domains (6) summary
      cd05046
      Location:660 → 933
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd00096
      Location:242 → 302
      Ig; Immunoglobulin domain
      cd05760
      Location:146 → 222
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:475 → 539
      IGc2; Immunoglobulin C-2 Type
      smart00221
      Location:671 → 931
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:468 → 551
      IG_like; Immunoglobulin like

    5. NM_152882.4 → NP_690621.1  inactive tyrosine-protein kinase 7 isoform d precursor

      See identical proteins and their annotated locations for NP_690621.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (PTK7-4) uses an alternate splice site and lacks an exon in the coding region, but maintains the reading frame, compared to variant PTK7-1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AF531871, AI140260, AK291016, CA389442
      Consensus CDS
      CCDS4887.1
      UniProtKB/Swiss-Prot
      Q13308
      Related
      ENSP00000326029.3, ENST00000352931.6
      Conserved Domains (9) summary
      cd05046
      Location:734 → 1007
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd00096
      Location:242 → 302
      Ig; Immunoglobulin domain
      cd05760
      Location:146 → 222
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:520 → 574
      IGc2; Immunoglobulin C-2 Type
      smart00221
      Location:745 → 1005
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:231 → 301
      IG; Immunoglobulin
      smart00410
      Location:38 → 112
      IG_like; Immunoglobulin like
      pfam07679
      Location:412 → 498
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:414 → 498
      Ig; Immunoglobulin domain

    RNA

    1. NR_072997.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an internal exon, compared to variant PTK7-1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant PTK7-1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC014626, CA389442, DA048438
      Related
      ENST00000470019.5

    2. NR_072998.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (PTK7-5) lacks an internal exon, compared to variant PTK7-1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant PTK7-1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF531872, AI140260, AK291016, CA389442
      Related
      ENST00000230418.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43076314..43161715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514765.3 → XP_011513067.1  inactive tyrosine-protein kinase 7 isoform X1

      Conserved Domains (9) summary
      cd05046
      Location:758 → 1031
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd00096
      Location:250 → 310
      Ig; Immunoglobulin domain
      cd05760
      Location:154 → 230
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:573 → 637
      IGc2; Immunoglobulin C-2 Type
      smart00221
      Location:769 → 1029
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:239 → 309
      IG; Immunoglobulin
      smart00410
      Location:566 → 649
      IG_like; Immunoglobulin like
      pfam07679
      Location:420 → 506
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:422 → 506
      Ig; Immunoglobulin domain

    2. XM_011514766.3 → XP_011513068.1  inactive tyrosine-protein kinase 7 isoform X2

      Conserved Domains (6) summary
      cd05046
      Location:668 → 941
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      cd00096
      Location:250 → 310
      Ig; Immunoglobulin domain
      cd05760
      Location:154 → 230
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
      smart00408
      Location:483 → 547
      IGc2; Immunoglobulin C-2 Type
      smart00221
      Location:679 → 939
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:476 → 559
      IG_like; Immunoglobulin like

    3. XM_047419157.1 → XP_047275113.1  inactive tyrosine-protein kinase 7 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      42905060..42990493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356064.1 → XP_054212039.1  inactive tyrosine-protein kinase 7 isoform X1

    2. XM_054356065.1 → XP_054212040.1  inactive tyrosine-protein kinase 7 isoform X2

    3. XM_054356066.1 → XP_054212041.1  inactive tyrosine-protein kinase 7 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152883.1: Suppressed sequence

      Description
      NM_152883.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13308.2 GenPept UniProtKB/Swiss-Prot:Q13308

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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