U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    BRD1 bromodomain containing 1 [ Homo sapiens (human) ]

    Gene ID: 23774, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    BRD1provided by HGNC
    Official Full Name
    bromodomain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:1102
    See related
    Ensembl:ENSG00000100425 MIM:604589; AllianceGenome:HGNC:1102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRL; BRPF1; BRPF2
    Summary
    This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in testis (RPKM 11.6), bone marrow (RPKM 4.4) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BRD1 in Genome Data Viewer
    Location:
    22q13.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (49773278..49827873, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50277574..50332170, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50166926..50221521, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50156966-50157749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50157750-50158532 Neighboring gene ribosomal protein L5 pseudogene 35 Neighboring gene Sharpr-MPRA regulatory region 11654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50199181-50199681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50209067-50209610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50209611-50210153 Neighboring gene suppressor of cytokine signaling 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50218197-50218776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13923 Neighboring gene uncharacterized LOC105377205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13924 Neighboring gene basic proline-rich protein-like Neighboring gene sterile alpha motif domain-containing protein 1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13927 Neighboring gene uncharacterized LOC124905147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50250325-50250985 Neighboring gene zinc finger BED-type containing 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis. Klein K, et al. Sci Rep, 2018 Jul 24. PMID 30042400, Free PMC Article
    2. The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation. Paternoster V, et al. Transl Psychiatry, 2022 Aug 8. PMID 35941107, Free PMC Article
    3. DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele. Dyrvig M, et al. PLoS One, 2017. PMID 28095495, Free PMC Article
    4. Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA. Liu L, et al. J Struct Biol, 2012 Oct. PMID 22820306
    5. Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples. Li Z, et al. Technol Cancer Res Treat, 2021 Jan-Dec. PMID 34482774, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.
      Title: The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.
    2. Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.
      Title: Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.
    3. HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
      Title: HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
    4. Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
      Title: Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
    5. our data point to a cell type- and a stimulus-specific function of BRD1. Inhibiting BRD1 could have potential beneficial effects in rheumatoid arthritis via decreasing the proliferation of synovial fibroblasts. Anti-inflammatory effects were limited and only observed in monocyte-derived macrophages
      Title: Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.
    6. Results show that interaction of sulfatide with BRD1 induced acetylation and promoted integrin alpha V gene transcription in hepatocellular carcinoma cells.
      Title: BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide.
    7. There was no association between SNPs in the BRD1 and ZBED4 genes and schizophrenia in the Chinese population.
      Title: No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population.
    8. TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers.
      Title: CHA2DS2-VASc score and blood biomarkers to identify patients with atrial high-rate episodes and paroxysmal atrial fibrillation.
    9. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2 have been presented.
      Title: Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.
    10. Reduced BRD1 expression is associated with Schizophrenia.
      Title: DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A comprehensive family-based replication study of schizophrenia genes.
    EBI GWAS Catalog
    Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
    EBI GWAS Catalog
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of bromodomain containing 1 (BRD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • DKFZp686F0325

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K12 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K5 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K8 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of developmental process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone H3-K14 acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    bromodomain-containing protein 1
    Names
    BR140-like protein
    bromodomain and PHD finger-containing protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304808.3 → NP_001291737.1  bromodomain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001291737.1

      Status: REVIEWED

      Source sequence(s)
      AK292428, Z98885
      Consensus CDS
      CCDS77686.1
      UniProtKB/TrEMBL
      Q86X06
      Related
      ENSP00000385858.1, ENST00000404760.6
      Conserved Domains (5) summary
      cd05839
      Location:1058 → 1173
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566 → 663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:139 → 591
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like

    2. NM_001304809.1 → NP_001291738.1  bromodomain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001291738.1

      Status: REVIEWED

      Source sequence(s)
      AA969405, AB209216, CR456408
      Consensus CDS
      CCDS14080.1
      UniProtKB/Swiss-Prot
      A6ZJA4, O95696
      UniProtKB/TrEMBL
      Q86X06
      Related
      ENSP00000384076.1, ENST00000404034.5
      Conserved Domains (5) summary
      cd05839
      Location:927 → 1042
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566 → 663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:139 → 591
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like

    3. NM_001349940.2 → NP_001336869.1  bromodomain-containing protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      Z98885
      UniProtKB/TrEMBL
      Q86X06
      Conserved Domains (5) summary
      cd05839
      Location:976 → 1091
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:620 → 712
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like
      cl26518
      Location:139 → 392
      EPL1; Enhancer of polycomb-like

    4. NM_001349941.2 → NP_001336870.1  bromodomain-containing protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      Z98885
      UniProtKB/TrEMBL
      Q86X06
      Conserved Domains (5) summary
      cd05839
      Location:1053 → 1168
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566 → 658
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like
      cl26518
      Location:139 → 606
      EPL1; Enhancer of polycomb-like

    5. NM_001349942.2 → NP_001336871.1  bromodomain-containing protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      Z98885
      UniProtKB/TrEMBL
      Q9Y4Q3
      Conserved Domains (2) summary
      cd05839
      Location:544 → 659
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:52 → 149
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

    6. NM_001394548.1 → NP_001381477.1  bromodomain-containing protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      Z98885
      UniProtKB/TrEMBL
      Q86X06
      Conserved Domains (5) summary
      cd05839
      Location:1056 → 1171
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:564 → 661
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:139 → 549
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like

    7. NM_001394549.1 → NP_001381478.1  bromodomain-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      Z98885
      UniProtKB/TrEMBL
      Q86X06
      Conserved Domains (4) summary
      cd05839
      Location:1051 → 1166
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:564 → 656
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:139 → 604
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

    8. NM_001394550.1 → NP_001381479.1  bromodomain-containing protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      Z98885
      Conserved Domains (2) summary
      cd05839
      Location:413 → 528
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:52 → 149
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

    9. NM_001394551.1 → NP_001381480.1  bromodomain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      Z98885
      Consensus CDS
      CCDS14080.1
      UniProtKB/Swiss-Prot
      A6ZJA4, O95696
      UniProtKB/TrEMBL
      Q86X06
      Conserved Domains (5) summary
      cd05839
      Location:927 → 1042
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566 → 663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:139 → 591
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like

    10. NM_001394552.1 → NP_001381481.1  bromodomain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      Z98885
      Consensus CDS
      CCDS14080.1
      UniProtKB/Swiss-Prot
      A6ZJA4, O95696
      UniProtKB/TrEMBL
      Q86X06
      Related
      ENSP00000216267.8, ENST00000216267.12
      Conserved Domains (5) summary
      cd05839
      Location:927 → 1042
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566 → 663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:139 → 591
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like

    RNA

    1. NR_146334.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z98885

    2. NR_146335.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z98885

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      49773278..49827873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441274.1 → XP_047297230.1  bromodomain-containing protein 1 isoform X5

    2. XM_017028722.3 → XP_016884211.2  bromodomain-containing protein 1 isoform X2

    3. XM_017028716.2 → XP_016884205.1  bromodomain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      Q86X06
      Conserved Domains (5) summary
      cd05839
      Location:1058 → 1173
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:566 → 663
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5141
      Location:139 → 591
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15702
      Location:271 → 388
      ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:47 → 196
      EPL1; Enhancer of polycomb-like

    4. XM_047441278.1 → XP_047297234.1  bromodomain-containing protein 1 isoform X9

    5. XM_047441281.1 → XP_047297237.1  bromodomain-containing protein 1 isoform X2

    6. XM_047441277.1 → XP_047297233.1  bromodomain-containing protein 1 isoform X8

      Related
      ENSP00000388027.2, ENST00000438393.6

    7. XM_017028718.2 → XP_016884207.1  bromodomain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      Q86X06

    8. XM_047441276.1 → XP_047297232.1  bromodomain-containing protein 1 isoform X7

    9. XM_047441273.1 → XP_047297229.1  bromodomain-containing protein 1 isoform X4

    10. XM_047441271.1 → XP_047297227.1  bromodomain-containing protein 1 isoform X1

    11. XM_047441275.1 → XP_047297231.1  bromodomain-containing protein 1 isoform X6

    12. XM_047441272.1 → XP_047297228.1  bromodomain-containing protein 1 isoform X3

    13. XM_047441280.1 → XP_047297236.1  bromodomain-containing protein 1 isoform X12

    14. XM_047441283.1 → XP_047297239.1  bromodomain-containing protein 1 isoform X14

    15. XM_047441282.1 → XP_047297238.1  bromodomain-containing protein 1 isoform X13

    16. XM_047441279.1 → XP_047297235.1  bromodomain-containing protein 1 isoform X11

    RNA

    1. XR_007067961.1 RNA Sequence

    2. XR_007067962.1 RNA Sequence

    3. XR_007067965.1 RNA Sequence

    4. XR_007067964.1 RNA Sequence

    5. XR_007067963.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      50277574..50332170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325421.1 → XP_054181396.1  bromodomain-containing protein 1 isoform X5

    2. XM_054325417.1 → XP_054181392.1  bromodomain-containing protein 1 isoform X2

    3. XM_054325420.1 → XP_054181395.1  bromodomain-containing protein 1 isoform X5

    4. XM_054325425.1 → XP_054181400.1  bromodomain-containing protein 1 isoform X9

    5. XM_054325429.1 → XP_054181404.1  bromodomain-containing protein 1 isoform X2

    6. XM_054325424.1 → XP_054181399.1  bromodomain-containing protein 1 isoform X8

    7. XM_054325426.1 → XP_054181401.1  bromodomain-containing protein 1 isoform X10

    8. XM_054325423.1 → XP_054181398.1  bromodomain-containing protein 1 isoform X7

    9. XM_054325419.1 → XP_054181394.1  bromodomain-containing protein 1 isoform X4

    10. XM_054325416.1 → XP_054181391.1  bromodomain-containing protein 1 isoform X1

    11. XM_054325422.1 → XP_054181397.1  bromodomain-containing protein 1 isoform X6

    12. XM_054325418.1 → XP_054181393.1  bromodomain-containing protein 1 isoform X3

    13. XM_054325428.1 → XP_054181403.1  bromodomain-containing protein 1 isoform X12

    14. XM_054325431.1 → XP_054181406.1  bromodomain-containing protein 1 isoform X14

    15. XM_054325430.1 → XP_054181405.1  bromodomain-containing protein 1 isoform X13

    16. XM_054325427.1 → XP_054181402.1  bromodomain-containing protein 1 isoform X11

    RNA

    1. XR_008485373.1 RNA Sequence

    2. XR_008485374.1 RNA Sequence

    3. XR_008485377.1 RNA Sequence

    4. XR_008485376.1 RNA Sequence

    5. XR_008485375.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014577.1: Suppressed sequence

      Description
      NM_014577.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95696.1 GenPept UniProtKB/Swiss-Prot:O95696

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous