DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: DYRK1Bprovided by HGNC
Official Full Name: dual specificity tyrosine phosphorylation regulated kinase 1Bprovided by HGNC
Primary source: HGNC:HGNC:3092
See related: Ensembl:ENSG00000105204 MIM:604556; AllianceGenome:HGNC:3092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRK; AOMS3
Summary: This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression: Broad expression in testis (RPKM 21.5), prostate (RPKM 4.7) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (39825350..39834162, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (42630272..42639084, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (40315990..40324802, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.
Title: Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.
Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.
Title: Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.
Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.
Title: Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.
DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
Title: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
Title: Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.
Title: Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.
Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.
Title: Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.
Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.
Title: Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.
Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
Title: Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
Human cytomegalovirus(HCMV) modulates cellular dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B) during placental replication which may have implications for congenital HCMV pathogenesis and represent promising antiviral targets.
Title: Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Abdominal obesity-metabolic syndrome 3 MedGen: C4014361 OMIM: 615812 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in myoblast fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 1B

Names: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; minibrain-related kinase; mirk protein kinase

NP_004705.1

EC 2.7.12.1

NP_006474.1

EC 2.7.12.1

NP_006475.1

EC 2.7.12.1

XP_005259455.1

EC 2.7.12.1

XP_047295623.1

EC 2.7.12.1

XP_047295624.1

EC 2.7.12.1

XP_047295625.1

EC 2.7.12.1

XP_054178558.1

EC 2.7.12.1

XP_054178559.1

EC 2.7.12.1

XP_054178560.1

EC 2.7.12.1

XP_054178561.1

EC 2.7.12.1

XP_054187621.1

EC 2.7.12.1

XP_054187622.1

EC 2.7.12.1

XP_054187623.1

EC 2.7.12.1

XP_054187624.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_034145.1 RefSeqGene

Range

5072..13884

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004714.3 → NP_004705.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

See identical proteins and their annotated locations for NP_004705.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as 'a') represents the longest transcript and encodes the longest isoform (p69, also known as isoform a).

Source sequence(s)

Y17999

Consensus CDS

CCDS12543.1

UniProtKB/Swiss-Prot

O75258, O75788, O75789, Q9Y463

UniProtKB/TrEMBL

B3KQI0

Related

ENSP00000312789.4, ENST00000323039.10

Conserved Domains (1) summary

cd14226
Location:97 → 436

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_006483.3 → NP_006474.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

See identical proteins and their annotated locations for NP_006474.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as 'b') uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (p65, also known as isoform b) is shorter than isoform p69.

Source sequence(s)

BI964831, Y17999

Consensus CDS

CCDS46075.1

UniProtKB/TrEMBL

B3KQI0

Related

ENSP00000403182.1, ENST00000430012.6

Conserved Domains (1) summary

cd14226
Location:97 → 396

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_006484.3 → NP_006475.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66

See identical proteins and their annotated locations for NP_006475.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as 'c') lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (p66, also known as isoform c) is shorter than isoform p69.

Source sequence(s)

BI964831, Y17999

Consensus CDS

CCDS12544.1

UniProtKB/TrEMBL

B3KQI0

Related

ENSP00000221803.4, ENST00000348817.7

Conserved Domains (1) summary

cd14226
Location:97 → 408

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

39825350..39834162 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439669.1 → XP_047295625.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3
XM_047439668.1 → XP_047295624.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2
XM_047439667.1 → XP_047295623.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

UniProtKB/TrEMBL

A0A9H4CVU7

Related

ENSP00000469863.2, ENST00000593685.5
XM_005259398.5 → XP_005259455.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

See identical proteins and their annotated locations for XP_005259455.1

UniProtKB/Swiss-Prot

O75258, O75788, O75789, Q9Y463

UniProtKB/TrEMBL

B3KQI0

Conserved Domains (1) summary

cd14226
Location:97 → 436

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

Reference GRCh38.p14 PATCHES

Genomic

NW_009646206.1 Reference GRCh38.p14 PATCHES

Range

85226..94038 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331646.1 → XP_054187621.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

UniProtKB/TrEMBL

A0A9H4CVU7
XM_054331647.1 → XP_054187622.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2
XM_054331648.1 → XP_054187623.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3
XM_054331649.1 → XP_054187624.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

UniProtKB/Swiss-Prot

O75258, O75788, O75789, Q9Y463

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

42630272..42639084 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322583.1 → XP_054178558.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

UniProtKB/TrEMBL

A0A9H4CVU7
XM_054322584.1 → XP_054178559.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2
XM_054322585.1 → XP_054178560.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3
XM_054322586.1 → XP_054178561.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

UniProtKB/Swiss-Prot

O75258, O75788, O75789, Q9Y463