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    CARHSP1 calcium regulated heat stable protein 1 [ Homo sapiens (human) ]

    Gene ID: 23589, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CARHSP1provided by HGNC
    Official Full Name
    calcium regulated heat stable protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17150
    See related
    Ensembl:ENSG00000153048 MIM:616885; AllianceGenome:HGNC:17150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSDC1; CRHSP24; CRHSP-24
    Summary
    Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule; cytoplasmic exosome (RNase complex); and cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 17.9), adrenal (RPKM 11.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CARHSP1 in Genome Data Viewer
    Location:
    16p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (8852942..8869006, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (8885694..8901743, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8946799..8962863, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891090-8891784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891785-8892479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7178 Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8923335-8923936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8929774-8930308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8930309-8930841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8940347-8940938 Neighboring gene uncharacterized LOC100130283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8953773-8954487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8959743-8960380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8960381-8961020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7181 Neighboring gene CARHSP1 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr16:8971783-8971898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10357 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8976345-8976845 Neighboring gene LITAF domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response. Hou H, et al. J Biol Chem, 2011 Mar 18. PMID 21177848, Free PMC Article
    2. Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma. Zhu GD, et al. Cell Death Dis, 2021 Jul 21. PMID 34290231, Free PMC Article
    3. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. Groblewski GE, et al. J Biol Chem, 1998 Aug 28. PMID 9712905
    4. CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells. Schäfer C, et al. Am J Physiol Gastrointest Liver Physiol, 2003 Oct. PMID 12801884
    5. Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor α. Fan Y, et al. J Biol Chem, 2011 Nov 25. PMID 21990353, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma.
      Title: Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma.
    2. Increased miR-155 relieves chronic inflammation by a negative feedback loop and plays a protective role during atherosclerosis-associated foam cell formation by signaling through the miR-155-CARHSP1-TNF-alpha pathway.
      Title: miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1.
    3. CARHSP1 inhibits hepatic gluconeogenic gene expression via repression of PPARalpha
      Title: Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor α.
    4. CRHSP-24 participates in oxidative stress response via a dynamic and temporal association between stress granules and processing bodies.
      Title: Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response.
    5. Data suggest that CARHSP1 is a TNF-alpha mRNA stability enhancer required for effective TNF-alpha production, demonstrating the importance of both stabilization and destabilization pathways in regulating the TNF-alpha mRNA half-life.
      Title: CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111446

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calcium-regulated heat-stable protein 1
    Names
    calcium regulated heat stable protein 1, 24kDa
    calcium-regulated heat-stable protein (24kD)
    calcium-regulated heat-stable protein of 24 kDa

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042476.2 → NP_001035941.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001035941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167, BC001333, BQ004670, HY090855
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000379838.2, ENST00000396593.6
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    2. NM_001278260.2 → NP_001265189.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000481550.1, ENST00000611932.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    3. NM_001278261.2 → NP_001265190.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000483591.1, ENST00000618335.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    4. NM_001278262.2 → NP_001265191.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000480542.1, ENST00000614449.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    5. NM_001278263.1 → NP_001265192.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167, BM920489, BQ004670, HY090855
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000455284.1, ENST00000561530.5
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    6. NM_001278264.2 → NP_001265193.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000480144.1, ENST00000619881.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    7. NM_001278265.2 → NP_001265194.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000478055.1, ENST00000610831.4
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    8. NM_001278266.2 → NP_001265195.1  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_001265195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000455855.1, ENST00000567554.5
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    9. NM_014316.4 → NP_055131.2  calcium-regulated heat-stable protein 1

      See identical proteins and their annotated locations for NP_055131.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-9 encode the same protein.
      Source sequence(s)
      AC022167
      Consensus CDS
      CCDS10537.1
      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Related
      ENSP00000311847.4, ENST00000311052.10
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      8852942..8869006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522444.3 → XP_011520746.1  calcium-regulated heat-stable protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011520746.1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
      UniProtKB/TrEMBL
      H3BNU9
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    2. XM_047433886.1 → XP_047289842.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

    3. XM_047433884.1 → XP_047289840.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

    4. XM_047433885.1 → XP_047289841.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      8885694..8901743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379981.1 → XP_054235956.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

    2. XM_054379982.1 → XP_054235957.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

    3. XM_054379980.1 → XP_054235955.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

    4. XM_054379983.1 → XP_054235958.1  calcium-regulated heat-stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2V2.2 GenPept UniProtKB/Swiss-Prot:Q9Y2V2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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