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    CIAO2A cytosolic iron-sulfur assembly component 2A [ Homo sapiens (human) ]

    Gene ID: 84191, updated on 10-Dec-2024

    Summary

    Official Symbol
    CIAO2Aprovided by HGNC
    Official Full Name
    cytosolic iron-sulfur assembly component 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:26235
    See related
    Ensembl:ENSG00000166797 MIM:618382; AllianceGenome:HGNC:26235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIA2A; FAM96A
    Summary
    Predicted to enable metal ion binding activity. Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytosol and nucleoplasm. Part of cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 13.5), duodenum (RPKM 11.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CIAO2A in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64072565..64093838, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (61879723..61900991, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64364764..64386037, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64171093-64171988 Neighboring gene microRNA 422a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9543 Neighboring gene Sharpr-MPRA regulatory region 4498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64186155-64186656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9546 Neighboring gene uncharacterized LOC101928988 Neighboring gene death associated protein kinase 2 Neighboring gene Sharpr-MPRA regulatory region 12240 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64264631-64265378 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64277639-64278140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64290279-64290780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9548 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64318331-64318496 Neighboring gene NANOG hESC enhancer GRCh37_chr15:64330918-64331419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64342658-64343204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9552 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64385112-64385674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9556 Neighboring gene Sharpr-MPRA regulatory region 7733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9557 Neighboring gene sorting nexin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64437862-64438378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64445879-64446610 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22875

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein maturation by [4Fe-4S] cluster transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of cytosolic [4Fe-4S] assembly targeting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cytosolic iron-sulfur assembly component 2A
    Names
    MIP18 family protein FAM96A
    family with sequence similarity 96 member A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014812.3NP_001014812.1  cytosolic iron-sulfur assembly component 2A isoform b

      See identical proteins and their annotated locations for NP_001014812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon that causes a frame-shift compared to variant 1. The resulting shorter isoform (b) has a distinct C-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC021541
      Consensus CDS
      CCDS45278.1
      UniProtKB/Swiss-Prot
      Q9H5X1
      Related
      ENSP00000369644.3, ENST00000380290.8
      Conserved Domains (1) summary
      cl00941
      Location:3996
      FeS_assembly_P; Iron-sulfur cluster assembly protein
    2. NM_001289108.2NP_001276037.1  cytosolic iron-sulfur assembly component 2A isoform b

      See identical proteins and their annotated locations for NP_001276037.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal coding exon that causes a frame-shift and differs at the 3' end compared to variant 1. The resulting shorter isoform (b) has a distinct C-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC021541
      Consensus CDS
      CCDS45278.1
      UniProtKB/Swiss-Prot
      Q9H5X1
      Related
      ENSP00000454079.1, ENST00000557835.6
      Conserved Domains (1) summary
      cl00941
      Location:3996
      FeS_assembly_P; Iron-sulfur cluster assembly protein
    3. NM_032231.7NP_115607.1  cytosolic iron-sulfur assembly component 2A isoform a

      See identical proteins and their annotated locations for NP_115607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC021541
      Consensus CDS
      CCDS10189.1
      UniProtKB/Swiss-Prot
      A6NKS1, B2R5F8, B7Z8Z5, Q9H5X1
      UniProtKB/TrEMBL
      H0YKV4
      Related
      ENSP00000300030.3, ENST00000300030.8
      Conserved Domains (1) summary
      cl00941
      Location:39156
      FeS_assembly_P; Iron-sulfur cluster assembly protein

    RNA

    1. NR_110310.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a novel exon in the 5' region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC021541

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      64072565..64093838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      61879723..61900991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)