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    ZNF777 zinc finger protein 777 [ Homo sapiens (human) ]

    Gene ID: 27153, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZNF777provided by HGNC
    Official Full Name
    zinc finger protein 777provided by HGNC
    Primary source
    HGNC:HGNC:22213
    See related
    Ensembl:ENSG00000196453 MIM:619298; AllianceGenome:HGNC:22213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of cell population proliferation; and protein heterooligomerization. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 4.5), brain (RPKM 4.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF777 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149431363..149461062, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150613213..150642913, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149128454..149158153, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375559 Neighboring gene uncharacterized LOC101928733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26814 Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149118879-149119378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18759 Neighboring gene zinc finger protein 746 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:149191224-149192423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149193218-149194161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26816 Neighboring gene tRNA-Cys (anticodon GCA) 16-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1285

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015694.3NP_056509.2  zinc finger protein 777

      Status: VALIDATED

      Source sequence(s)
      AB033111, AC073314, BC023985, BX444270, DR763452
      Consensus CDS
      CCDS43675.1
      UniProtKB/Swiss-Prot
      Q8N2R2, Q8N659, Q9ULD5
      Related
      ENSP00000247930.4, ENST00000247930.5
      Conserved Domains (7) summary
      smart00349
      Location:285343
      KRAB; krueppel associated box
      COG5048
      Location:640826
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10263
      Location:6186
      PRK10263; DNA translocase FtsK; Provisional
      sd00017
      Location:696716
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:669686
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:546568
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:199255
      DUF3669; Zinc finger protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149431363..149461062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249980.4XP_005250037.1  zinc finger protein 777 isoform X1

      Conserved Domains (8) summary
      cd07765
      Location:329368
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:329387
      KRAB; krueppel associated box
      COG5048
      Location:684870
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:740760
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:713730
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:738760
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:752776
      zf-H2C2_2; Zinc-finger double domain
      pfam14353
      Location:681730
      CpXC; CpXC protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150613213..150642913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357906.1XP_054213881.1  zinc finger protein 777 isoform X1