U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DAPL1 death associated protein like 1 [ Homo sapiens (human) ]

    Gene ID: 92196, updated on 9-Dec-2024

    Summary

    Official Symbol
    DAPL1provided by HGNC
    Official Full Name
    death associated protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:21490
    See related
    Ensembl:ENSG00000163331 AllianceGenome:HGNC:21490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable several functions, including death domain binding activity; ribosome binding activity; and translation initiation factor binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of CD8-positive, alpha-beta T cell activation; and ribosome hibernation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in esophagus (RPKM 59.4), skin (RPKM 46.5) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DAPL1 in Genome Data Viewer
    Location:
    2q24.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (158795317..158815990)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (159251305..159278068)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (159651829..159672502)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene plakophilin 4 Neighboring gene uncharacterized LOC105373715 Neighboring gene Sharpr-MPRA regulatory region 6347 Neighboring gene PKP4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:159579921-159580426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:159581263-159581762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:159601320-159601820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:159601821-159602321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:159639703-159640202 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53410 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53422 Neighboring gene uncharacterized LOC124907901 Neighboring gene olfactory receptor family 7 subfamily E member 89 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 28 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation initiation factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of CD8-positive, alpha-beta T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosome hibernation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosome hibernation ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    death-associated protein-like 1
    Names
    early epithelial differentiation-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017920.3NP_001017920.2  death-associated protein-like 1

      See identical proteins and their annotated locations for NP_001017920.2

      Status: VALIDATED

      Source sequence(s)
      AC079877, AF086541, AY324399, BC127683, CD675155
      Consensus CDS
      CCDS33307.1
      UniProtKB/Swiss-Prot
      A0PJW8, A0PJW9, B9EIK6
      UniProtKB/TrEMBL
      M1E9T5
      Related
      ENSP00000309538.4, ENST00000309950.8
      Conserved Domains (1) summary
      pfam15228
      Location:13106
      DAP; Death-associated protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      158795317..158815990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      159251305..159278068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)