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    TMEM150C transmembrane protein 150C [ Homo sapiens (human) ]

    Gene ID: 441027, updated on 9-Dec-2024

    Summary

    Official Symbol
    TMEM150Cprovided by HGNC
    Official Full Name
    transmembrane protein 150Cprovided by HGNC
    Primary source
    HGNC:HGNC:37263
    See related
    Ensembl:ENSG00000249242 MIM:617292; AllianceGenome:HGNC:37263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TTN3
    Summary
    This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 19.6), adrenal (RPKM 16.2) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TMEM150C in Genome Data Viewer
    Location:
    4q21.22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (82483176..82562253, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (85812454..85891532, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83404329..83483406, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15529 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:83350279-83351074 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:83351075-83351870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21664 Neighboring gene heterogeneous nuclear ribonucleoprotein D like Neighboring gene enolase-phosphatase 1 Neighboring gene uncharacterized LOC105377310 Neighboring gene ribosomal protein L7a pseudogene 26 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10449 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83482867-83483366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83506651-83507180 Neighboring gene Sharpr-MPRA regulatory region 8782 Neighboring gene PTPN11 pseudogene 5 Neighboring gene long intergenic non-protein coding RNA 575

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proprioception ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane protein 150C
    Names
    tentonin 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080506.3NP_001073975.1  transmembrane protein 150C isoform 1

      See identical proteins and their annotated locations for NP_001073975.1

      Status: REVIEWED

      Source sequence(s)
      AC067942, BC147019, BF508344
      Consensus CDS
      CCDS47087.1
      UniProtKB/Swiss-Prot
      B7Z4J5, B7Z4L3, B7Z692, B7Z6X6, B9EJG8
      Related
      ENSP00000403438.2, ENST00000449862.7
      Conserved Domains (1) summary
      pfam10277
      Location:8217
      Frag1; Frag1/DRAM/Sfk1 family
    2. NM_001353454.2NP_001340383.1  transmembrane protein 150C isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC067942, AK297434, BF508344
      Conserved Domains (1) summary
      pfam10277
      Location:38247
      Frag1; Frag1/DRAM/Sfk1 family
    3. NM_001353455.2NP_001340384.1  transmembrane protein 150C isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC067942, AK297512, BF508344
      Conserved Domains (1) summary
      pfam10277
      Location:8142
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      82483176..82562253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      85812454..85891532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)