FNDC5 fibronectin type III domain containing 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FNDC5provided by HGNC
Official Full Name: fibronectin type III domain containing 5provided by HGNC
Primary source: HGNC:HGNC:20240
See related: Ensembl:ENSG00000160097 MIM:611906; AllianceGenome:HGNC:20240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FRCP2; irisin
Summary: This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression: Biased expression in heart (RPKM 13.5), liver (RPKM 8.6) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p35.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (32862268..32872484, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (32722061..32732277, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (33327869..33338085, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FNDC5 affects invasion and migration of oral cancer by inhibiting PI3K/Akt/Snail signaling pathway.
Title: FNDC5 affects invasion and migration of oral cancer by inhibiting PI3K/Akt/Snail signaling pathway.
Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.
Title: Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.
Irisin in thyroid diseases.
Title: Irisin in thyroid diseases.
Irisin influences the in vitro differentiation of human mesenchymal stromal cells, promoting a tendency toward beiging adipogenesis.
Title: Irisin influences the in vitro differentiation of human mesenchymal stromal cells, promoting a tendency toward beiging adipogenesis.
Plasma BDNF/Irisin Ratio Associates with Cognitive Function in Older People.
Title: Plasma BDNF/Irisin Ratio Associates with Cognitive Function in Older People.
Plasma irisin and the brain-derived neurotrophic factor levels in sedentary subjects: effect of 8-weeks lifestyle intervention.
Title: Plasma irisin and the brain-derived neurotrophic factor levels in sedentary subjects: effect of 8-weeks lifestyle intervention.
FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway.
Title: FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway.
The emerging roles of irisin in vascular calcification.
Title: The emerging roles of irisin in vascular calcification.
Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients.
Title: Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients.
Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.
Title: Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.

Submit: New GeneRIF Correction See all GeneRIFs (337)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74541 (e-PCR)
- UniSTS:39272

D1S3028 (e-PCR)
- UniSTS:68274

G60185 (e-PCR)
- UniSTS:137444

SHGC-74545 (e-PCR)
- UniSTS:35558

D1S3615 (e-PCR)
- UniSTS:28658

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of brown fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of brown fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to muscle activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fibronectin type III domain-containing protein 5

Names: fibronectin type III repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171940.2 → NP_001165411.2 fibronectin type III domain-containing protein 5 isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001165411.2

Status: REVIEWED

Source sequence(s)

AC114493

UniProtKB/TrEMBL

A0A0A0MRR6

Conserved Domains (2) summary

cd00063
Location:34 → 124

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam16066
Location:149 → 172

DUF4808; Domain of unknown function (DUF4808)
NM_001171941.3 → NP_001165412.1 fibronectin type III domain-containing protein 5 isoform 1

See identical proteins and their annotated locations for NP_001165412.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1).

Source sequence(s)

AC114493, BC033123, BC062297, CV815003, DA393478

Consensus CDS

CCDS65483.1

UniProtKB/Swiss-Prot

Q8NAU1

Related

ENSP00000476320.1, ENST00000496770.1

Conserved Domains (2) summary

cd00063
Location:5 → 49

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam16066
Location:76 → 109

DUF4808; Domain of unknown function (DUF4808)
NM_153756.3 → NP_715637.2 fibronectin type III domain-containing protein 5 isoform 2 preproprotein

See identical proteins and their annotated locations for NP_715637.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, compared to variant 1. It initiates translation from an alternate "AUA" start codon that is conserved as an "AUG" start codon in orthologs. The encoded isoform (2) is longer and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AC114493, AK092102, BC033123, BE502835

Consensus CDS

CCDS369.2

UniProtKB/Swiss-Prot

A0AA34QVI5, A6NMC9, D3DPQ6, Q6P6D9, Q7Z676, Q8NAU1

UniProtKB/TrEMBL

A0A0A0MRR6

Related

ENSP00000362570.5, ENST00000373471.9

Conserved Domains (2) summary

cd00063
Location:34 → 124

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam16066
Location:151 → 184

DUF4808; Domain of unknown function (DUF4808)