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    P2RY10 P2Y receptor family member 10 [ Homo sapiens (human) ]

    Gene ID: 27334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P2RY10provided by HGNC
    Official Full Name
    P2Y receptor family member 10provided by HGNC
    Primary source
    HGNC:HGNC:19906
    See related
    Ensembl:ENSG00000078589 MIM:300529; AllianceGenome:HGNC:19906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPS2; P2Y10; LYPSR2
    Summary
    The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016]
    Expression
    Biased expression in lymph node (RPKM 13.0), appendix (RPKM 8.0) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See P2RY10 in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (78945391..78963727)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (77382251..77400598)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (78200888..78219224)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29788 Neighboring gene microRNA 4328 Neighboring gene P2Y receptor family member 10B, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:78385499-78386160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29789 Neighboring gene G protein-coupled receptor 174

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor that mediates eosinophil degranulation. Hwang SM, et al. Clin Exp Allergy, 2018 Aug. PMID 29700886
    2. Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Murakami M, et al. Biochem Biophys Res Commun, 2008 Jul 11. PMID 18466763
    3. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Gurusamy M, et al. Nat Commun, 2021 Nov 23. PMID 34815397, Free PMC Article
    4. Receptors for purines and pyrimidines. Ralevic V, et al. Pharmacol Rev, 1998 Sep. PMID 9755289
    5. Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases. Berchtold S, et al. FEBS Lett, 1999 Sep 24. PMID 10570953

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.
      Title: The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.
    2. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
      Title: G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
    3. Our data show that the LysoPS-induced eosinophil degranulation most likely occurs through P2Y10. These findings suggest that LysoPS plays a specific role in eosinophils and introduces the possibility of LysoPS/P2Y10-based therapeutics in the treatment of eosinophilic diseases.
      Title: Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor that mediates eosinophil degranulation.
    4. The P2Y(10) receptor is the first receptor identified as a dual lysophospholipid receptor.
      Title: Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    putative P2Y purinoceptor 10
    Names
    G-protein coupled purinergic receptor P2Y10
    P2Y-like receptor
    lysophosphatidylserine receptor 2
    purinergic receptor P2Y, G-protein coupled, 10
    purinergic receptor P2Y10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013276.2 RefSeqGene

      Range
      5060..23396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001324218.2 → NP_001311147.1  putative P2Y purinoceptor 10 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR compared to variant 1.
      Source sequence(s)
      BX104083, DB213380, Z82200
      Consensus CDS
      CCDS14442.1
      UniProtKB/Swiss-Prot
      D3DTE5, O00398, Q4VBN7, Q86V16
      UniProtKB/TrEMBL
      A8K7X3
      Conserved Domains (1) summary
      cd15153
      Location:35 → 316
      7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001324221.2 → NP_001311150.1  putative P2Y purinoceptor 10 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region and initiates translation at an upstream alternate start codon compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a.
      Source sequence(s)
      BX104083, DB131258, Z82200
      UniProtKB/TrEMBL
      A8K7X3
      Conserved Domains (1) summary
      pfam00001
      Location:69 → 322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001324225.2 → NP_001311154.1  putative P2Y purinoceptor 10 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an exon and lacks an exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a longer N-terminus than isoform a.
      Source sequence(s)
      BX104083, DA817144, Z82200
      UniProtKB/TrEMBL
      A8K7X3

    4. NM_014499.4 → NP_055314.1  putative P2Y purinoceptor 10 isoform a

      See identical proteins and their annotated locations for NP_055314.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AW294346, BC051875, BX104083, Z82200
      Consensus CDS
      CCDS14442.1
      UniProtKB/Swiss-Prot
      D3DTE5, O00398, Q4VBN7, Q86V16
      UniProtKB/TrEMBL
      A8K7X3
      Related
      ENSP00000171757.2, ENST00000171757.3
      Conserved Domains (1) summary
      cd15153
      Location:35 → 316
      7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_198333.3 → NP_938147.1  putative P2Y purinoceptor 10 isoform a

      See identical proteins and their annotated locations for NP_938147.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the 5' UTR compared to variant 1.
      Source sequence(s)
      BC051875, BX104083, CD639881, Z82200
      Consensus CDS
      CCDS14442.1
      UniProtKB/Swiss-Prot
      D3DTE5, O00398, Q4VBN7, Q86V16
      UniProtKB/TrEMBL
      A8K7X3
      Related
      ENSP00000443138.1, ENST00000544091.1
      Conserved Domains (1) summary
      cd15153
      Location:35 → 316
      7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      78945391..78963727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441998.1 → XP_047297954.1  putative P2Y purinoceptor 10 isoform X1

      UniProtKB/Swiss-Prot
      D3DTE5, O00398, Q4VBN7, Q86V16
      UniProtKB/TrEMBL
      A8K7X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      77382251..77400598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326853.1 → XP_054182828.1  putative P2Y purinoceptor 10 isoform X1

      UniProtKB/Swiss-Prot
      D3DTE5, O00398, Q4VBN7, Q86V16
      UniProtKB/TrEMBL
      A8K7X3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00398.1 GenPept UniProtKB/Swiss-Prot:O00398

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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