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    PIAS2 protein inhibitor of activated STAT 2 [ Homo sapiens (human) ]

    Gene ID: 9063, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PIAS2provided by HGNC
    Official Full Name
    protein inhibitor of activated STAT 2provided by HGNC
    Primary source
    HGNC:HGNC:17311
    See related
    Ensembl:ENSG00000078043 MIM:603567; AllianceGenome:HGNC:17311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4
    Summary
    This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
    Expression
    Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PIAS2 in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (46803218..46920145, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (46993864..47110811, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44383181..44500108, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene ribosomal protein S21 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9420 Neighboring gene ST8SIA5 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr18:44374579-44375080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13281 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13282 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:44447848-44449047 Neighboring gene uncharacterized LOC124904294 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:44479065-44479890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44490867-44491368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44491369-44491868 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:44496866-44497619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44499127-44499879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9423 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44546997-44547496 Neighboring gene elongin A3 family member D, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44552405-44553168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44553169-44553932 Neighboring gene elongin A3 family member B, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe. Rodrigues JS, et al. Nat Commun, 2024 May 14. PMID 38744818, Free PMC Article
    2. Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation. Guo J, et al. Viruses, 2017 Sep 30. PMID 28973998, Free PMC Article
    3. Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis. Gui Z, et al. Ann Transplant, 2019 Oct 4. PMID 31582715, Free PMC Article
    4. PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia. Magalhaes J, et al. Mol Psychiatry, 2021 Oct. PMID 34234281, Free PMC Article
    5. PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways. Yang SH, et al. Mol Cell, 2006 May 19. PMID 16713578

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe.
      Title: dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe.
    2. Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.
      Title: Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.
    3. Expression of PIAS Genes in Migraine Patients.
      Title: Expression of PIAS Genes in Migraine Patients.
    4. PIAS2-mediated blockade of IFN-beta signaling: a basis for sporadic Parkinson disease dementia.
      Title: PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.
    5. SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
      Title: SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
    6. PIAS genes as disease markers in bipolar disorder.
      Title: PIAS genes as disease markers in bipolar disorder.
    7. We are the first to reveal that mutations of rs644731 in the PIAS2 gene were significantly correlated with the progression of interstitial fibrosis and tubular atrophy in kidney transplant recipients.
      Title: Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis.
    8. the results presented demonstrate that in heat-stressed HeLa cells, p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of transactivation by Elk-1.
      Title: p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells.
    9. PIAS1expression of PIAS1 gene was increased in patients with MS compared to healthy subjects; also, there was a significant correlation between the expression of PIAS1 and PIAS2 genes with disease severity of multiple sclerosis
      Title: The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis.
    10. results indicated that PIAS2-mediated SUMOylation constrained HCV replication
      Title: Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102682

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase PIAS2
    Names
    DAB2-interacting protein
    E3 SUMO-protein transferase PIAS2
    androgen receptor-interacting protein 3
    msx-interacting zinc finger protein
    protein inhibitor of activated STAT X
    zinc finger, MIZ-type containing 4
    NP_001310975.1
    NP_001310976.1
    NP_001310977.1
    NP_001310978.1
    NP_001310980.1
    NP_001310981.1
    NP_001310982.1
    NP_001310983.1
    NP_001310984.1
    NP_001310986.1
    NP_001310987.1
    NP_001310988.1
    NP_001310989.1
    NP_001340962.1
    NP_001340963.1
    NP_001340964.1
    NP_001340965.1
    NP_001340966.1
    NP_001340967.1
    NP_001340968.1
    NP_004662.2
    NP_775298.1
    XP_006722636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029865.2 RefSeqGene

      Range
      5026..119315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001324046.2 → NP_001310975.1  E3 SUMO-protein ligase PIAS2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain

    2. NM_001324047.2 → NP_001310976.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    3. NM_001324048.2 → NP_001310977.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain

    4. NM_001324049.2 → NP_001310978.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain

    5. NM_001324051.2 → NP_001310980.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    6. NM_001324052.2 → NP_001310981.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    7. NM_001324053.2 → NP_001310982.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    8. NM_001324054.2 → NP_001310983.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    9. NM_001324055.2 → NP_001310984.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    10. NM_001324057.2 → NP_001310986.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    11. NM_001324058.2 → NP_001310987.1  E3 SUMO-protein ligase PIAS2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, BC111060
      UniProtKB/TrEMBL
      A0A087WUY7, Q2TA77
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:342 → 390
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:145 → 282
      PINIT; PINIT domain

    12. NM_001324059.2 → NP_001310988.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Related
      ENSP00000479025.1, ENST00000592212.5
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    13. NM_001324060.2 → NP_001310989.1  E3 SUMO-protein ligase PIAS2 isoform NY

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform NY from PMID: 15301740.
      Source sequence(s)
      AC090241, AF361054
      UniProtKB/Swiss-Prot
      O75928
      Related
      ENST00000592011.5

    14. NM_001354033.2 → NP_001340962.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    15. NM_001354034.2 → NP_001340963.1  E3 SUMO-protein ligase PIAS2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147 → 296
      PINIT; PINIT domain

    16. NM_001354035.2 → NP_001340964.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain

    17. NM_001354036.2 → NP_001340965.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain

    18. NM_001354037.2 → NP_001340966.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138 → 282
      PINIT; PINIT domain
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    19. NM_001354038.2 → NP_001340967.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    20. NM_001354039.2 → NP_001340968.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334 → 381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138 → 287
      PINIT; PINIT domain

    21. NM_004671.5 → NP_004662.2  E3 SUMO-protein ligase PIAS2 isoform beta

      See identical proteins and their annotated locations for NP_004662.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) encodes isoform (beta).
      Source sequence(s)
      AC090241, AF077954, AF086240, BG718291
      Consensus CDS
      CCDS32824.1
      UniProtKB/Swiss-Prot
      O75927, O75928, Q96BT5, Q96KE3
      Related
      ENSP00000465676.1, ENST00000585916.6
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147 → 296
      PINIT; PINIT domain

    22. NM_173206.4 → NP_775298.1  E3 SUMO-protein ligase PIAS2 isoform alpha

      See identical proteins and their annotated locations for NP_775298.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) utilizes an alternate 3' coding exon, compared to variant beta, resulting in a shorter isoform (alpha) that has a unique C-terminus compared to isoform beta.
      Source sequence(s)
      AC090241, BC015190, BG718291
      Consensus CDS
      CCDS32825.1
      UniProtKB/TrEMBL
      A0A087WUY7
      Related
      ENSP00000317163.6, ENST00000324794.11
      Conserved Domains (3) summary
      smart00513
      Location:11 → 45
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343 → 390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147 → 296
      PINIT; PINIT domain

    RNA

    1. NR_136684.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, AF086240, AK308143

    2. NR_136685.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, AK294801

    3. NR_148699.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373

    4. NR_148700.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373

    5. NR_148701.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373

    6. NR_148702.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373

    7. NR_148703.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      46803218..46920145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722573.3 → XP_006722636.1  E3 SUMO-protein ligase PIAS2 isoform X1

      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:50 → 84
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:381 → 429
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:184 → 321
      PINIT; PINIT domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      46993864..47110811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75928.3 GenPept UniProtKB/Swiss-Prot:O75928

    Gene LinkOut

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