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    ZMYM6 zinc finger MYM-type containing 6 [ Homo sapiens (human) ]

    Gene ID: 9204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZMYM6provided by HGNC
    Official Full Name
    zinc finger MYM-type containing 6provided by HGNC
    Primary source
    HGNC:HGNC:13050
    See related
    Ensembl:ENSG00000163867 MIM:613567; AllianceGenome:HGNC:13050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYM; ZBED7; ZNF258; Buster2; ZNF198L4
    Summary
    Predicted to enable DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 6.2), bone marrow (RPKM 5.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZMYM6 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (34986165..35031945, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (34848836..34894616, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35451766..35497546, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 199, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 634 Neighboring gene transmembrane protein 35B Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35462847-35463058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:35496848-35497374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:35497375-35497899 Neighboring gene uncharacterized LOC124903990 Neighboring gene ribosomal protein L12 pseudogene 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and mapping of members of the MYM family. Smedley D, et al. Genomics, 1999 Sep 1. PMID 10486218
    2. The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. Herrmann CH, et al. J Cell Sci, 2001 Apr. PMID 11282025
    3. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. Lin X, et al. J Biol Chem, 2002 May 10. PMID 11884399
    4. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. Hayward A, et al. PLoS One, 2013. PMID 23533661, Free PMC Article
    5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYM-type protein 6
    Names
    transposon-derived Buster2 transposase-like protein
    zinc finger protein 258
    zinc finger, BED-type containing 7
    zinc finger, MYM-type 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007167.4 → NP_009098.3  zinc finger MYM-type protein 6

      See identical proteins and their annotated locations for NP_009098.3

      Status: VALIDATED

      Source sequence(s)
      AL833263, BC068534, BC107880
      Consensus CDS
      CCDS387.2
      UniProtKB/Swiss-Prot
      B4DRJ6, O95789, Q32Q23, Q4G108, Q5SVZ9, Q5SW00, Q69YL4, Q96IY0, Q9NWF1, Q9P2J4
      Related
      ENSP00000349708.4, ENST00000357182.9
      Conserved Domains (2) summary
      smart00746
      Location:193 → 228
      TRASH; metallochaperone-like domain
      pfam06467
      Location:131 → 174
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      34986165..35031945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      34848836..34894616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024933.1: Suppressed sequence

      Description
      NM_001024933.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

    2. NM_145310.2: Suppressed sequence

      Description
      NM_145310.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

    3. NM_153248.2: Suppressed sequence

      Description
      NM_153248.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95789.2 GenPept UniProtKB/Swiss-Prot:O95789

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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