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    SERPINB12 serpin family B member 12 [ Homo sapiens (human) ]

    Gene ID: 89777, updated on 27-Nov-2024

    Summary

    Official Symbol
    SERPINB12provided by HGNC
    Official Full Name
    serpin family B member 12provided by HGNC
    Primary source
    HGNC:HGNC:14220
    See related
    Ensembl:ENSG00000166634 MIM:615662; AllianceGenome:HGNC:14220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YUKOPIN
    Summary
    Enables serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward skin (RPKM 27.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SERPINB12 in Genome Data Viewer
    Location:
    18q21.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (63519110..63569329)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (63724229..63774441)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61209602..61236562)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 4 homolog B Neighboring gene proteasome 26S subunit, ATPase 5 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13468 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:61094350-61095549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9530 Neighboring gene VPS4B-SERPINB5 intergenic CAGE-defined mid-level expression enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:61134418-61135617 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:61142940-61144139 Neighboring gene serpin family B member 5 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:61178432-61178952 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:61255863-61257062 Neighboring gene serpin family B member 13 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:61308020-61309219 Neighboring gene serpin family B member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    serpin B12
    Names
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12
    serpin peptidase inhibitor, clade B (ovalbumin), member 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307928.2NP_001294857.1  serpin B12 isoform 1

      See identical proteins and their annotated locations for NP_001294857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090307
      Consensus CDS
      CCDS77194.1
      UniProtKB/Swiss-Prot
      Q96P63
      Related
      ENSP00000372218.1, ENST00000382768.2
      Conserved Domains (1) summary
      cd02059
      Location:4425
      ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
    2. NM_080474.2NP_536722.1  serpin B12 isoform 2

      See identical proteins and their annotated locations for NP_536722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded idoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC090307, AF411191
      Consensus CDS
      CCDS11984.1
      UniProtKB/Swiss-Prot
      Q3SYB4, Q96P63
      Related
      ENSP00000269491.1, ENST00000269491.6
      Conserved Domains (1) summary
      cd02059
      Location:4405
      ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      63519110..63569329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266778.4XP_005266835.2  serpin B12 isoform X1

      Conserved Domains (1) summary
      cd02059
      Location:16437
      ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
    2. XM_011526246.2XP_011524548.1  serpin B12 isoform X2

      Conserved Domains (1) summary
      cd02059
      Location:11432
      ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
    3. XM_011526248.2XP_011524550.1  serpin B12 isoform X3

      See identical proteins and their annotated locations for XP_011524550.1

      UniProtKB/Swiss-Prot
      Q96P63
      Conserved Domains (1) summary
      cd02059
      Location:4425
      ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
    4. XM_011526249.1XP_011524551.1  serpin B12 isoform X3

      See identical proteins and their annotated locations for XP_011524551.1

      UniProtKB/Swiss-Prot
      Q96P63
      Conserved Domains (1) summary
      cd02059
      Location:4425
      ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      63724229..63774441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319322.1XP_054175297.1  serpin B12 isoform X1

    2. XM_054319323.1XP_054175298.1  serpin B12 isoform X2

    3. XM_054319324.1XP_054175299.1  serpin B12 isoform X3

    4. XM_054319325.1XP_054175300.1  serpin B12 isoform X3