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    RNF152 ring finger protein 152 [ Homo sapiens (human) ]

    Gene ID: 220441, updated on 9-Dec-2024

    Summary

    Official Symbol
    RNF152provided by HGNC
    Official Full Name
    ring finger protein 152provided by HGNC
    Primary source
    HGNC:HGNC:26811
    See related
    Ensembl:ENSG00000176641 MIM:616512; AllianceGenome:HGNC:26811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables small GTPase binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein ubiquitination. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney (RPKM 29.4), liver (RPKM 4.9) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RNF152 in Genome Data Viewer
    Location:
    18q21.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (61808067..61894412, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (62011910..62098286, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (59475300..59560240, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904315 Neighboring gene long intergenic non-protein coding RNA 1544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:59483460-59484019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9500 Neighboring gene uncharacterized LOC105372159 Neighboring gene uncharacterized LOC112268209 Neighboring gene Sharpr-MPRA regulatory region 15585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9501 Neighboring gene ribose 5-phosphate isomerase A pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ39176, MGC138161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in organelle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF152
    Names
    RING-type E3 ubiquitin transferase RNF152
    NP_775828.1
    XP_005266707.1
    XP_005266709.1
    XP_011524180.1
    XP_011524181.1
    XP_016881101.1
    XP_047293305.1
    XP_054174259.1
    XP_054174260.1
    XP_054174261.1
    XP_054174262.1
    XP_054174263.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173557.3NP_775828.1  E3 ubiquitin-protein ligase RNF152

      See identical proteins and their annotated locations for NP_775828.1

      Status: VALIDATED

      Source sequence(s)
      AC105094, AK122758
      Consensus CDS
      CCDS11978.1
      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000316628.3, ENST00000312828.4
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      61808067..61894412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266652.4XP_005266709.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_005266709.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    2. XM_017025612.2XP_016881101.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    3. XM_005266650.4XP_005266707.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_005266707.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    4. XM_011525878.3XP_011524180.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_011524180.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    5. XM_011525879.3XP_011524181.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_011524181.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Conserved Domains (1) summary
      cd16548
      Location:1155
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
    6. XM_047437349.1XP_047293305.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      62011910..62098286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318284.1XP_054174259.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
    2. XM_054318285.1XP_054174260.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
    3. XM_054318286.1XP_054174261.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
    4. XM_054318287.1XP_054174262.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
    5. XM_054318288.1XP_054174263.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0