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    GFOD3P Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogene [ Homo sapiens (human) ]

    Gene ID: 57212, updated on 17-Sep-2024

    Summary

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    Official Symbol
    GFOD3Pprovided by HGNC
    Official Full Name
    Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:29052
    See related
    Ensembl:ENSG00000293478 AllianceGenome:HGNC:29052
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDAM; KIAA0495; TP73-AS1
    Expression
    Ubiquitous expression in testis (RPKM 8.0), ovary (RPKM 7.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GFOD3P in Genome Data Viewer
    Location:
    1p36.32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (3735984..3747373, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (3247585..3258974, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3652548..3663937, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TP73 antisense RNA 3 Neighboring gene tumor protein p73 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 63 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 64 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3596796-3596963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3597253-3597988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3600129-3600889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3605575-3606096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3606097-3606618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3623899-3624726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3624727-3625555 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3631158-3631397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3634425-3634984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3634985-3635544 Neighboring gene TP73 antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3636665-3637223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3637224-3637783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3637784-3638342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 65 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3650019-3650807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3661686-3662521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3662522-3663358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3678785-3679286 Neighboring gene coiled-coil domain containing 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3679287-3679786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3687696-3688374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3689661-3690176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3690177-3690692 Neighboring gene MPRA functional variant 1:3691528:A:G red blood cell enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3691725-3692240 Neighboring gene small integral membrane protein 1 (Vel blood group)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel tumor suppressor encoded by a 1p36.3 lncRNA functions as a phosphoinositide-binding protein repressing AKT phosphorylation/activation and promoting autophagy. Li L, et al. Cell Death Differ, 2023 May. PMID 36813924, Free PMC Article
    2. KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells. Pang JC, et al. Brain Pathol, 2010 Nov. PMID 20477830, Free PMC Article
    3. Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma. Wong KY, et al. Mol Cancer, 2015 Sep 26. PMID 26410378, Free PMC Article
    4. LncRNA TP73-AS1 predicts the prognosis of bladder cancer patients and functions as a suppressor for bladder cancer by EMT pathway. Tuo Z, et al. Biochem Biophys Res Commun, 2018 May 23. PMID 29625110
    5. LncRNA TP73‑AS1 predicts poor prognosis and promotes cell proliferation in ovarian cancer via cell cycle and apoptosis regulation. Li X, et al. Mol Med Rep, 2018 Jul. PMID 29750302

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of long noncoding RNA TP73-AS1 expression confers resistance to temozolomide in human glioblastoma cells.
      Title: Downregulation of long noncoding RNA TP73-AS1 expression confers resistance to temozolomide in human glioblastoma cells.
    2. LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging.
      Title: LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging.
    3. Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer.
      Title: Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer.
    4. Silencing of TP73-AS1 impairs prostate cancer cell proliferation and induces apoptosis via regulation of TP73.
      Title: Silencing of TP73-AS1 impairs prostate cancer cell proliferation and induces apoptosis via regulation of TP73.
    5. Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis.
      Title: Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis.
    6. LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
      Title: LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
    7. LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.
      Title: LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.
    8. lncRNA TP73-AS1 Regulates miR-21/PTEN Axis to Affect Cell Proliferation in Acute Myeloid Leukemia.
      Title: lncRNA TP73-AS1 Regulates miR-21/PTEN Axis to Affect Cell Proliferation in Acute Myeloid Leukemia.
    9. LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-beta1 signaling.
      Title: LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-β1 signaling.
    10. LncRNA TP73-AS1 enhances the malignant properties of pancreatic ductal adenocarcinoma by increasing MMP14 expression through miRNA -200a sponging.
      Title: LncRNA TP73-AS1 enhances the malignant properties of pancreatic ductal adenocarcinoma by increasing MMP14 expression through miRNA -200a sponging.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • TP73 antisense RNA 1 (non-protein coding)
    • p53-dependent apoptosis modulator

    Clone Names

    • KIAA0495, MGC138189

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_033708.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment, compared to variant 1.
      Source sequence(s)
      AL136528, BC035073, BC089039
      Related
      ENST00000647831.1

    2. NR_033709.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, compared to variant 1.
      Source sequence(s)
      AL136528, BC089039

    3. NR_033710.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment, compared to variant 1.
      Source sequence(s)
      AL133648, AL136528, BC089039

    4. NR_033711.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AB007964, AL136528, BC089039
      Related
      ENST00000452079.5

    5. NR_033712.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 1.
      Source sequence(s)
      AL136528, BC013872
      Related
      ENST00000418088.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      3735984..3747373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      3247585..3258974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207306.2: Suppressed sequence

      Description
      NM_207306.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials