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    ANGPTL7 angiopoietin like 7 [ Homo sapiens (human) ]

    Gene ID: 10218, updated on 27-Nov-2024

    Summary

    Official Symbol
    ANGPTL7provided by HGNC
    Official Full Name
    angiopoietin like 7provided by HGNC
    Primary source
    HGNC:HGNC:24078
    See related
    Ensembl:ENSG00000171819 MIM:618517; AllianceGenome:HGNC:24078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AngX; CDT6; dJ647M16.1
    Summary
    Enables identical protein binding activity. Involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart (RPKM 2.5), gall bladder (RPKM 2.2) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ANGPTL7 in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11189355..11195981)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10730945..10737571)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11249412..11256038)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene RNA, U6 small nuclear 537, pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:11237905-11238443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11249765-11250265 Neighboring gene MPRA-validated peak73 silencer Neighboring gene RNA, U6 small nuclear 291, pseudogene Neighboring gene ribosomal protein L39 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    angiopoietin-related protein 7
    Names
    angiopoietin-like factor (CDT6)
    angiopoietin-like protein 7
    cornea-derived transcript 6 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021146.4NP_066969.1  angiopoietin-related protein 7 precursor

      See identical proteins and their annotated locations for NP_066969.1

      Status: VALIDATED

      Source sequence(s)
      BC001881
      Consensus CDS
      CCDS128.1
      UniProtKB/Swiss-Prot
      B2R9B2, F1T0A6, O43827, Q4ZGK4
      Related
      ENSP00000366015.3, ENST00000376819.4
      Conserved Domains (2) summary
      cd00087
      Location:129341
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl25732
      Location:37109
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      11189355..11195981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424430.1XP_047280386.1  angiopoietin-related protein 7 isoform X2

    2. XM_017000004.2XP_016855493.1  angiopoietin-related protein 7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      10730945..10737571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333755.1XP_054189730.1  angiopoietin-related protein 7 isoform X2

    2. XM_054333754.1XP_054189729.1  angiopoietin-related protein 7 isoform X1