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    P2RY14 purinergic receptor P2Y14 [ Homo sapiens (human) ]

    Gene ID: 9934, updated on 10-Dec-2024

    Summary

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    Official Symbol
    P2RY14provided by HGNC
    Official Full Name
    purinergic receptor P2Y14provided by HGNC
    Primary source
    HGNC:HGNC:16442
    See related
    Ensembl:ENSG00000174944 MIM:610116; AllianceGenome:HGNC:16442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2Y14; BPR105; GPR105
    Summary
    The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in esophagus (RPKM 4.9), placenta (RPKM 4.7) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See P2RY14 in Genome Data Viewer
    Location:
    3q25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151212117..151278542, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (153963174..154029607, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150929905..150996330, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene RNA, 5S ribosomal pseudogene 145 Neighboring gene Sharpr-MPRA regulatory region 7583 Neighboring gene G protein-coupled receptor 171 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959259-150959858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959859-150960456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20700 Neighboring gene Sharpr-MPRA regulatory region 3159 Neighboring gene SET pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:151033994-151035193 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. P2-pyrimidinergic receptors and their ligands. Müller CE. Curr Pharm Des, 2002. PMID 12369950
    2. Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. Skelton L, et al. J Immunol, 2003 Aug 15. PMID 12902497
    3. GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. Moore DJ, et al. Brain Res Mol Brain Res, 2003 Oct 21. PMID 14559350
    4. Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. Costanzi S, et al. J Med Chem, 2004 Oct 21. PMID 15481977, Free PMC Article
    5. Pharmacological effects mediated by UDP-glucose that are independent of P2Y14 receptor expression. Scrivens M, et al. Pharmacol Res, 2005 Jun. PMID 15829433

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of the pro-inflammatory P2Y14 receptor in the non-vasectomized and vasectomized human epididymis.
      Title: Expression of the pro-inflammatory P2Y14 receptor in the non-vasectomized and vasectomized human epididymis.
    2. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
      Title: The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
    3. UDP-glucose, a cellular danger signal, and nucleotide receptor P2Y14 enhance the invasion of human extravillous trophoblast cells.
      Title: UDP-glucose, a cellular danger signal, and nucleotide receptor P2Y14 enhance the invasion of human extravillous trophoblast cells.
    4. P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation.
      Title: P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation.
    5. P2Y14R is downregulated in hCPCs derived from heart failure patients. Augmenting P2Y14R expression levels in aged/diseased hCPCs antagonizes senescence and improves functional responses.
      Title: Empowering human cardiac progenitor cells by P2Y(14) nucleotide receptor overexpression.
    6. Present study suggests that P2Y14 expression could be used as a phenotypic marker to further dissect placental HSPCs.
      Title: The expression of P2Y14, a purinergic G-protein coupled receptor, defines functionally distinct subpopulations in placenta-derived hematopoietic stem progenitor cells.
    7. Data show that thymidine 5'-O-monophosphorothioate (TMPS) diminished UDPG-evoked intracellular calcium mobilization in a stable HEK293T cell line overexpressing the P2Y14 receptor.
      Title: Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation.
    8. UDP-glucose activates P2Y14 receptor and JAK2, increases STAT3 Tyr705 phosphorylation, and enhances transcription of HAS2.
      Title: Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
    9. PPTN as a highly selective high-affinity antagonist of the P2Y14-R.
      Title: A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.
    10. These results support the notion that UDP-glucose is a stable and potent proinflammatory mediator that promotes P2Y(14)-R-mediated neutrophil motility via Rho/Rho kinase activation.
      Title: The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of purinergic receptor P2Y, G-protein coupled, 14 (P2RY14) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0001

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled UDP receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    P2Y purinoceptor 14
    Names
    G protein coupled receptor for UDP-glucose
    G-protein coupled receptor 105
    P2Y(14) receptor
    P2Y14 receptor
    UDP-glucose receptor
    purinergic receptor P2Y, G-protein coupled, 14

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081455.2 → NP_001074924.1  P2Y purinoceptor 14

      See identical proteins and their annotated locations for NP_001074924.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC078816, BC034989, CD110153
      Consensus CDS
      CCDS3156.1
      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3
      Related
      ENSP00000408733.2, ENST00000424796.6
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 235
      7tm_4; Olfactory receptor

    2. NM_014879.4 → NP_055694.3  P2Y purinoceptor 14

      See identical proteins and their annotated locations for NP_055694.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC078816, BC034989
      Consensus CDS
      CCDS3156.1
      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3
      Related
      ENSP00000308361.3, ENST00000309170.8
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 235
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      151212117..151278542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513340.4 → XP_011511642.1  P2Y purinoceptor 14 isoform X1

      See identical proteins and their annotated locations for XP_011511642.1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 235
      7tm_4; Olfactory receptor

    2. XM_005247922.4 → XP_005247979.1  P2Y purinoceptor 14 isoform X1

      See identical proteins and their annotated locations for XP_005247979.1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 235
      7tm_4; Olfactory receptor

    3. XM_017007583.3 → XP_016863072.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 235
      7tm_4; Olfactory receptor

    4. XM_005247923.4 → XP_005247980.1  P2Y purinoceptor 14 isoform X1

      See identical proteins and their annotated locations for XP_005247980.1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 235
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      153963174..154029607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348645.1 → XP_054204620.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3

    2. XM_054348643.1 → XP_054204618.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3

    3. XM_054348644.1 → XP_054204619.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3

    4. XM_054348646.1 → XP_054204621.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      Q15391, Q8IYT7
      UniProtKB/TrEMBL
      A5JUU3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15391.1 GenPept UniProtKB/Swiss-Prot:Q15391

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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