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    IFNW1 interferon omega 1 [ Homo sapiens (human) ]

    Gene ID: 3467, updated on 9-Dec-2024

    Summary

    Official Symbol
    IFNW1provided by HGNC
    Official Full Name
    interferon omega 1provided by HGNC
    Primary source
    HGNC:HGNC:5448
    See related
    Ensembl:ENSG00000177047 MIM:147553; AllianceGenome:HGNC:5448
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IFNW1 in Genome Data Viewer
    Location:
    9p21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (21140632..21141832, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (21154492..21155692, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21140631..21141831, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interferon beta 1 Neighboring gene Sharpr-MPRA regulatory region 8746 Neighboring gene interferon omega 1 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28234 Neighboring gene interferon alpha 21 Neighboring gene interferon omega 1 pseudogene 15

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type I interferon receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in B cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in natural killer cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to exogenous dsRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type I interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interferon omega-1
    Names
    IFN-omega 1, interferon omega-1
    interferon alpha-II-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002177.3NP_002168.1  interferon omega-1 precursor

      See identical proteins and their annotated locations for NP_002168.1

      Status: REVIEWED

      Source sequence(s)
      AI860608, X02669
      Consensus CDS
      CCDS6496.1
      UniProtKB/Swiss-Prot
      P05000, Q13168, Q5U802, Q5VWD0, Q7M4P5
      UniProtKB/TrEMBL
      A0A7R8GUW6
      Related
      ENSP00000369578.2, ENST00000380229.4
      Conserved Domains (1) summary
      pfam00143
      Location:26185
      Interferon; Interferon alpha/beta domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      21140632..21141832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      21154492..21155692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)