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    SCGB1D1 secretoglobin family 1D member 1 [ Homo sapiens (human) ]

    Gene ID: 10648, updated on 27-Nov-2024

    Summary

    Official Symbol
    SCGB1D1provided by HGNC
    Official Full Name
    secretoglobin family 1D member 1provided by HGNC
    Primary source
    HGNC:HGNC:18395
    See related
    Ensembl:ENSG00000168515 MIM:615060; AllianceGenome:HGNC:18395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIPA; LPHA; LPNA
    Summary
    The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene product represents one component of a heterodimeric molecule present in human tears whose elution profile is consistent with prostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See SCGB1D1 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62190216..62193539)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62179483..62182807)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61957688..61961011)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61891773-61892354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61895837-61896336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61897363-61897864 Neighboring gene inner centromere protein Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61912955-61913116 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61942903-61943082 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61959742-61960242 Neighboring gene secretoglobin family 2A member 1 Neighboring gene secretoglobin family 1D member 2

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    secretoglobin family 1D member 1
    Names
    lipophilin A (uteroglobin family member)
    lipophilin-A
    prostatein-like lipophilin A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006552.2NP_006543.1  secretoglobin family 1D member 1 precursor

      See identical proteins and their annotated locations for NP_006543.1

      Status: REVIEWED

      Source sequence(s)
      AJ224171, AP002793, AP003306
      Consensus CDS
      CCDS8015.1
      UniProtKB/Swiss-Prot
      O95968
      Related
      ENSP00000303070.3, ENST00000306238.3
      Conserved Domains (1) summary
      pfam01099
      Location:2484
      Uteroglobin; Uteroglobin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62190216..62193539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62179483..62182807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)