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    H2AC14 H2A clustered histone 14 [ Homo sapiens (human) ]

    Gene ID: 8331, updated on 9-Dec-2024

    Summary

    Official Symbol
    H2AC14provided by HGNC
    Official Full Name
    H2A clustered histone 14provided by HGNC
    Primary source
    HGNC:HGNC:4727
    See related
    Ensembl:ENSG00000276368 MIM:602791; AllianceGenome:HGNC:4727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2A/E; H2AFE; HIST1H2AJ; dJ160A22.4
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
    Orthologs
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    Genomic context

    See H2AC14 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27814302..27814777, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27683976..27684451, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27782080..27782555, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27776213-27776811 Neighboring gene H2A clustered histone 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27777495-27778166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27778167-27778838 Neighboring gene H3 clustered histone 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24314 Neighboring gene H2B clustered histone 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24315 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27792023-27792664 Neighboring gene H4 clustered histone 11

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    histone cluster 1, H2aj
    Names
    H2A histone family, member E
    histone 1, H2aj
    histone cluster 1 H2A family member j

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021066.3NP_066544.1  histone cluster 1, H2aj

      See identical proteins and their annotated locations for NP_066544.1

      Status: REVIEWED

      Source sequence(s)
      AL049822
      Consensus CDS
      CCDS4628.1
      UniProtKB/Swiss-Prot
      A2RUU6, Q5JXQ5, Q99878
      UniProtKB/TrEMBL
      B2R5B3
      Related
      ENSP00000328484.4, ENST00000333151.5
      Conserved Domains (1) summary
      PTZ00017
      Location:1128
      PTZ00017; histone H2A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      27814302..27814777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      27683976..27684451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)