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    TADA2A transcriptional adaptor 2A [ Homo sapiens (human) ]

    Gene ID: 6871, updated on 9-Dec-2024

    Summary

    Official Symbol
    TADA2Aprovided by HGNC
    Official Full Name
    transcriptional adaptor 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:11531
    See related
    Ensembl:ENSG00000276234 MIM:602276; AllianceGenome:HGNC:11531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADA2; ADA2A; KL04P; hADA2; TADA2L
    Summary
    Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
    Annotation information
    Note: ADA2 is an official symbol GeneID: 51816 and an alias on GeneID: 687. GeneID: 6871 is frequently referred to as ADA2 in the literature, and publications belonging to GeneID:51816 are sometimes mis-associated with GeneID: 6871 [06 Jul 2018]
    Expression
    Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 4.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TADA2A in Genome Data Viewer
    Location:
    17q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37406886..37479725)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38397046..38466403)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35766977..35839830)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene small nucleolar RNA, H/ACA box 90 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35712269-35712768 Neighboring gene chromosome 17 open reading frame 78 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35768105-35768789 Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene dual specificity phosphatase 14 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene synergin gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12705

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of SAGA-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcriptional adapter 2-alpha
    Names
    ADA2-like protein
    transcriptional adaptor 2 alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166105.3NP_001159577.2  transcriptional adapter 2-alpha isoform a

      See identical proteins and their annotated locations for NP_001159577.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AC243654, AK225918, BC011753, DA244842
      Consensus CDS
      CCDS11319.1
      UniProtKB/TrEMBL
      A0A024R0U3, A0A024R0Y4
      Related
      ENSP00000481091.1, ENST00000615182.5
      Conserved Domains (1) summary
      COG5114
      Location:28440
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    2. NM_001291918.2NP_001278847.1  transcriptional adapter 2-alpha isoform b

      See identical proteins and their annotated locations for NP_001278847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AC243654, BC001172, DA244842
      Consensus CDS
      CCDS45656.1
      UniProtKB/TrEMBL
      A0A087WWR4
      Related
      ENSP00000480446.1, ENST00000620367.4
      Conserved Domains (1) summary
      COG5114
      Location:28272
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    3. NM_001488.5NP_001479.4  transcriptional adapter 2-alpha isoform a

      See identical proteins and their annotated locations for NP_001479.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AC243654, AK022767, BC011753
      Consensus CDS
      CCDS11319.1
      UniProtKB/TrEMBL
      A0A024R0U3, A0A024R0Y4
      Related
      ENSP00000477709.1, ENST00000612272.4
      Conserved Domains (1) summary
      COG5114
      Location:28440
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    4. NM_133439.4NP_597683.3  transcriptional adapter 2-alpha isoform b

      See identical proteins and their annotated locations for NP_597683.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AC243654, AK022767, BC001172
      Consensus CDS
      CCDS45656.1
      UniProtKB/TrEMBL
      A0A087WWR4
      Conserved Domains (1) summary
      COG5114
      Location:28272
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      37406886..37479725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024982.1XP_016880471.1  transcriptional adapter 2-alpha isoform X3

      Conserved Domains (1) summary
      COG5114
      Location:28386
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    2. XM_017024981.2XP_016880470.1  transcriptional adapter 2-alpha isoform X2

      Conserved Domains (1) summary
      COG5114
      Location:28420
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    3. XM_047436612.1XP_047292568.1  transcriptional adapter 2-alpha isoform X3

      Conserved Domains (1) summary
      COG5114
      Location:28386
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    4. XM_047436610.1XP_047292566.1  transcriptional adapter 2-alpha isoform X2

    5. XM_011525154.3XP_011523456.1  transcriptional adapter 2-alpha isoform X4

      See identical proteins and their annotated locations for XP_011523456.1

      Conserved Domains (1) summary
      COG5114
      Location:2377
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    6. XM_047436613.1XP_047292569.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13
    7. XM_047436609.1XP_047292565.1  transcriptional adapter 2-alpha isoform X1

      UniProtKB/TrEMBL
      A0A024R0U3, A0A024R0Y4
    8. XM_017024985.2XP_016880474.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13
      Conserved Domains (2) summary
      COG5114
      Location:3339
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
      pfam04433
      Location:273339
      SWIRM; SWIRM domain
    9. XM_017024983.2XP_016880472.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13
      Conserved Domains (2) summary
      COG5114
      Location:3339
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
      pfam04433
      Location:273339
      SWIRM; SWIRM domain

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1646042..1718895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329314.1XP_054185289.1  transcriptional adapter 2-alpha isoform X3

    2. XM_054329313.1XP_054185288.1  transcriptional adapter 2-alpha isoform X2

    3. XM_054329317.1XP_054185292.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13
    4. XM_054329315.1XP_054185290.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13
    5. XM_054329316.1XP_054185291.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      38397046..38466403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317020.1XP_054172995.1  transcriptional adapter 2-alpha isoform X3

    2. XM_054317018.1XP_054172993.1  transcriptional adapter 2-alpha isoform X2

    3. XM_054317016.1XP_054172991.1  transcriptional adapter 2-alpha isoform X1

      UniProtKB/Swiss-Prot
      A8MVD0, B3KMU9, O75478, Q9BVJ0, Q9UCW2, Q9UP49
      UniProtKB/TrEMBL
      A0A0S2Z4G1
    4. XM_054317019.1XP_054172994.1  transcriptional adapter 2-alpha isoform X3

    5. XM_054317017.1XP_054172992.1  transcriptional adapter 2-alpha isoform X2

    6. XM_054317021.1XP_054172996.1  transcriptional adapter 2-alpha isoform X4

    7. XM_054317024.1XP_054172999.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13
    8. XM_054317022.1XP_054172997.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13
    9. XM_054317023.1XP_054172998.1  transcriptional adapter 2-alpha isoform X5

      UniProtKB/TrEMBL
      B3KU13