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    MICALL1 MICAL like 1 [ Homo sapiens (human) ]

    Gene ID: 85377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MICALL1provided by HGNC
    Official Full Name
    MICAL like 1provided by HGNC
    Primary source
    HGNC:HGNC:29804
    See related
    Ensembl:ENSG00000100139 MIM:619563; AllianceGenome:HGNC:29804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRAB13; MICAL-L1
    Summary
    Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in cytoplasmic side of endosome membrane; late endosome; and recycling endosome membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 11.0), esophagus (RPKM 10.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MICALL1 in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37906297..37942822)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38367925..38404449)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38302304..38338829)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245068-38245590 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245591-38246112 Neighboring gene Sharpr-MPRA regulatory region 5684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38252750-38253250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38253251-38253751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38258557-38259056 Neighboring gene eukaryotic translation initiation factor 3 subunit L Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38276085-38276244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38290604-38291248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38294770-38295536 Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38300995-38301810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38301811-38302626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38302627-38303442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38303443-38304256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38306246-38307039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38313076-38313576 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38313949-38314111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314373-38314874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314875-38315374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329039-38329841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329842-38330643 Neighboring gene chromosome 22 open reading frame 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13705 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38360913-38361412 Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene microRNA 6820

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MICAL-L1 is required for cargo protein delivery to the cell surface. Sikora R, et al. Biol Open, 2021 Jun 15. PMID 34100897, Free PMC Article
    2. Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1. Frisby D, et al. Mol Biol Cell, 2024 Nov 1. PMID 39382837,
    3. Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway. Takahashi Y, et al. Int J Oncol, 2017 Aug. PMID 28714518
    4. MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium. Xie S, et al. J Cell Sci, 2019 Nov 14. PMID 31615969, Free PMC Article
    5. Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis. Reinecke JB, et al. Traffic, 2015 Jan. PMID 25287187, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1.
      Title: Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1.
    2. MICAL-L1 is required for cargo protein delivery to the cell surface.
      Title: MICAL-L1 is required for cargo protein delivery to the cell surface.
    3. Defining the protein and lipid constituents of tubular recycling endosomes.
      Title: Defining the protein and lipid constituents of tubular recycling endosomes.
    4. A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.
      Title: A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.
    5. Data support the notion that a pool of centriolar gamma-tubulin and/or alpha-tubulin-beta-tubulin heterodimers anchor MICAL-L1 to the centriole, where it might recruit EHD1 to promote ciliogenesis.
      Title: MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
    6. Findings found that ectopic expression of MICALL1 significantly inhibited the proliferation of HCT116 colorectal cancer cells. Also, MICALL1 expression was found to be suppressed in colorectal cancer with p53 mutations.
      Title: Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway.
    7. suggesting an EHD1-independent function for MICAL-L1 earlier in mitosis
      Title: Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosis.
    8. DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1
      Title: Diacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling.
    9. MICAL-L1-mediated recruitment of EHD1 to Src-containing recycling endosomes is required for the release of Src from the perinuclear endocytic recycling compartment in response to growth factor stimulation.
      Title: Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1.
    10. Cooperation of MICAL-L1, pacsin 2 (syndapin2), and phosphatidic acid in tubular recycling endosome biogenesis.
      Title: Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ45921, KIAA1668, DKFZp686M2226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma membrane tubulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in slow endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MICAL-like protein 1
    Names
    molecule interacting with Rab13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410818.1 → NP_001397747.1  MICAL-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL022311
      Consensus CDS
      CCDS93161.1
      UniProtKB/TrEMBL
      A0A7P0T9P2, H0Y6J8
      Related
      ENSP00000505762.1, ENST00000680578.1

    2. NM_001410819.1 → NP_001397748.1  MICAL-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL022311
      Consensus CDS
      CCDS93163.1
      UniProtKB/TrEMBL
      B0QY91, H0Y6J8
      Related
      ENSP00000416766.2, ENST00000424008.2

    3. NM_001410820.1 → NP_001397749.1  MICAL-like protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL022311
      Consensus CDS
      CCDS93162.1
      UniProtKB/TrEMBL
      B0QY86, H0Y6J8
      Related
      ENSP00000404543.2, ENST00000445494.6

    4. NM_033386.4 → NP_203744.1  MICAL-like protein 1 isoform 3

      See identical proteins and their annotated locations for NP_203744.1

      Status: VALIDATED

      Source sequence(s)
      AJ496196, AL022311, AL834373, CA307559, DR004306
      Consensus CDS
      CCDS13961.1
      UniProtKB/Swiss-Prot
      Q5TI16, Q7RTP5, Q8N3F8, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45
      UniProtKB/TrEMBL
      H0Y6J8
      Related
      ENSP00000215957.6, ENST00000215957.10
      Conserved Domains (3) summary
      cd09444
      Location:164 → 218
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      pfam00307
      Location:4 → 103
      CH; Calponin homology (CH) domain
      pfam12130
      Location:680 → 808
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      37906297..37942822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530471.3 → XP_011528773.1  MICAL-like protein 1 isoform X1

      UniProtKB/TrEMBL
      H0Y6J8
      Conserved Domains (3) summary
      cd09444
      Location:164 → 218
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      pfam00307
      Location:4 → 103
      CH; Calponin homology (CH) domain
      pfam12130
      Location:737 → 865
      DUF3585; Protein of unknown function (DUF3585)

    2. XM_011530472.3 → XP_011528774.1  MICAL-like protein 1 isoform X2

      UniProtKB/TrEMBL
      H0Y6J8
      Conserved Domains (3) summary
      cd09444
      Location:164 → 218
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      pfam00307
      Location:4 → 103
      CH; Calponin homology (CH) domain
      pfam12130
      Location:735 → 863
      DUF3585; Protein of unknown function (DUF3585)

    3. XM_047441552.1 → XP_047297508.1  MICAL-like protein 1 isoform X3

      UniProtKB/TrEMBL
      H0Y6J8

    4. XM_005261792.4 → XP_005261849.1  MICAL-like protein 1 isoform X4

      UniProtKB/TrEMBL
      H0Y6J8
      Conserved Domains (3) summary
      cd09444
      Location:164 → 218
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      pfam00307
      Location:4 → 103
      CH; Calponin homology (CH) domain
      pfam12130
      Location:678 → 806
      DUF3585; Protein of unknown function (DUF3585)

    5. XM_017029026.2 → XP_016884515.1  MICAL-like protein 1 isoform X6

      Conserved Domains (1) summary
      pfam12130
      Location:447 → 575
      DUF3585; Protein of unknown function (DUF3585)

    6. XM_011530476.3 → XP_011528778.1  MICAL-like protein 1 isoform X8

      Conserved Domains (2) summary
      cd09444
      Location:164 → 218
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      pfam00307
      Location:4 → 103
      CH; Calponin homology (CH) domain

    7. XM_047441554.1 → XP_047297510.1  MICAL-like protein 1 isoform X5

      UniProtKB/TrEMBL
      H0Y6J8

    8. XM_047441555.1 → XP_047297511.1  MICAL-like protein 1 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38367925..38404449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326059.1 → XP_054182034.1  MICAL-like protein 1 isoform X1

      UniProtKB/TrEMBL
      H0Y6J8

    2. XM_054326060.1 → XP_054182035.1  MICAL-like protein 1 isoform X2

      UniProtKB/TrEMBL
      H0Y6J8

    3. XM_054326061.1 → XP_054182036.1  MICAL-like protein 1 isoform X3

      UniProtKB/TrEMBL
      H0Y6J8

    4. XM_054326062.1 → XP_054182037.1  MICAL-like protein 1 isoform X4

      UniProtKB/TrEMBL
      H0Y6J8

    5. XM_054326064.1 → XP_054182039.1  MICAL-like protein 1 isoform X6

    6. XM_054326065.1 → XP_054182040.1  MICAL-like protein 1 isoform X7

    7. XM_054326066.1 → XP_054182041.1  MICAL-like protein 1 isoform X8

    8. XM_054326063.1 → XP_054182038.1  MICAL-like protein 1 isoform X5

      UniProtKB/TrEMBL
      H0Y6J8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N3F8.2 GenPept UniProtKB/Swiss-Prot:Q8N3F8

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