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    ZCCHC3 zinc finger CCHC-type containing 3 [ Homo sapiens (human) ]

    Gene ID: 85364, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZCCHC3provided by HGNC
    Official Full Name
    zinc finger CCHC-type containing 3provided by HGNC
    Primary source
    HGNC:HGNC:16230
    See related
    Ensembl:ENSG00000247315 MIM:618326; AllianceGenome:HGNC:16230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf99
    Summary
    Enables double-stranded DNA binding activity. Involved in cellular response to exogenous dsRNA; detection of virus; and positive regulation of innate immune response. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See ZCCHC3 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (297570..300321)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (340752..343503)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (278211..280965)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene defensin beta 132 Neighboring gene chromosome 20 open reading frame 96 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12561 Neighboring gene Sharpr-MPRA regulatory region 12860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17435 Neighboring gene NRSN2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12568 Neighboring gene SRY-box transcription factor 12

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with zinc finger, CCHC domain containing 3 (ZCCHC3) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104290

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to exogenous dsRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of RIG-I signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of RIG-I signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger CCHC domain-containing protein 3
    Names
    zinc finger, CCHC domain containing 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033089.7NP_149080.2  zinc finger CCHC domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      BC036469, BC069238
      Consensus CDS
      CCDS42844.1
      UniProtKB/Swiss-Prot
      Q3B7J3, Q6NT79, Q9NUD5
      Related
      ENSP00000484056.1, ENST00000500893.4
      Conserved Domains (1) summary
      cl26705
      Location:333386
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      297570..300321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      340752..343503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)