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    WDR90 WD repeat domain 90 [ Homo sapiens (human) ]

    Gene ID: 197335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    WDR90provided by HGNC
    Official Full Name
    WD repeat domain 90provided by HGNC
    Primary source
    HGNC:HGNC:26960
    See related
    Ensembl:ENSG00000161996 MIM:618290; AllianceGenome:HGNC:26960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POC16; C16orf15; C16orf16; C16orf17; C16orf18; C16orf19
    Summary
    Involved in cilium assembly. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 12.0), bone marrow (RPKM 4.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WDR90 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (648979..667830)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (653047..671905)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (699365..717830)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:687335-688109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:690840-691751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10209 Neighboring gene MAPK regulated corepressor interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10210 Neighboring gene uncharacterized LOC105371038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:709386-710276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:717843-718524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6937 Neighboring gene ras homolog family member T2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:724963-725497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6938 Neighboring gene rhomboid like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity. Steib E, et al. Elife, 2020 Sep 18. PMID 32946374, Free PMC Article
    2. Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis. Hamel V, et al. Curr Biol, 2017 Aug 21. PMID 28781053, Free PMC Article
    3. WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance. Valera-Pérez A, et al. Dev Comp Immunol, 2019 Nov. PMID 31276698
    4. Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. Chen Z, et al. Hum Mol Genet, 2013 Jun 15. PMID 23446634, Free PMC Article
    5. Novel Cul3 binding proteins function to remodel E3 ligase complexes. Wimuttisuk W, et al. BMC Cell Biol, 2014 Jul 10. PMID 25011449, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.
      Title: WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.
    2. Study describes WD repeat containing protein 90 (WDR90) as a new inflammasome component. Reconstitution experiments of the human inflammasome in HEK293cells demonstrated that WDR90 was able to physically interact with and to alter the cellular distribution of NLRC4, but not of NLRP3 and AIM2.
      Title: WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance.
    3. This study identified POB15 and POC16 as two proteins of the central core region, the distribution of which correlates with that of tubulin glutamylation; POB15 is an inner barrel protein within this region. Two poc16 mutants exhibit flagellar defects, indicating that POC16 is important for flagellum biogenesis. Human WDR90 is required for ciliogenesis, echoing the findings in Chlamydomonas.
      Title: Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36483, FLJ44660, KIAA1924

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 90

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145294.5 → NP_660337.3  WD repeat-containing protein 90

      See identical proteins and their annotated locations for NP_660337.3

      Status: VALIDATED

      Source sequence(s)
      AB067511, AK091062, AK092719, AK126622, Z92544
      Consensus CDS
      CCDS42092.1
      UniProtKB/Swiss-Prot
      Q0VA87, Q0VA88, Q6P048, Q6ZMS1, Q6ZTH1, Q8N202, Q8N221, Q8NBB8, Q96KV7, Q96PW4, Q96S18
      Related
      ENSP00000293879.4, ENST00000293879.9
      Conserved Domains (4) summary
      COG2319
      Location:1155 → 1549
      WD40; WD40 repeat [General function prediction only]
      pfam05018
      Location:5 → 181
      DUF667; Protein of unknown function (DUF667)
      sd00039
      Location:1392 → 1433
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:697 → 991
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      648979..667830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433744.1 → XP_047289700.1  WD repeat-containing protein 90 isoform X24

    2. XM_047433722.1 → XP_047289678.1  WD repeat-containing protein 90 isoform X1

    3. XM_047433734.1 → XP_047289690.1  WD repeat-containing protein 90 isoform X14

    4. XM_047433724.1 → XP_047289680.1  WD repeat-containing protein 90 isoform X3

    5. XM_047433735.1 → XP_047289691.1  WD repeat-containing protein 90 isoform X15

    6. XM_047433758.1 → XP_047289714.1  WD repeat-containing protein 90 isoform X38

    7. XM_047433747.1 → XP_047289703.1  WD repeat-containing protein 90 isoform X27

    8. XM_047433749.1 → XP_047289705.1  WD repeat-containing protein 90 isoform X29

    9. XM_047433725.1 → XP_047289681.1  WD repeat-containing protein 90 isoform X4

    10. XM_047433738.1 → XP_047289694.1  WD repeat-containing protein 90 isoform X18

    11. XM_047433760.1 → XP_047289716.1  WD repeat-containing protein 90 isoform X40

    12. XM_047433740.1 → XP_047289696.1  WD repeat-containing protein 90 isoform X20

    13. XM_047433730.1 → XP_047289686.1  WD repeat-containing protein 90 isoform X10

    14. XM_047433750.1 → XP_047289706.1  WD repeat-containing protein 90 isoform X30

    15. XM_047433753.1 → XP_047289709.1  WD repeat-containing protein 90 isoform X33

    16. XM_047433723.1 → XP_047289679.1  WD repeat-containing protein 90 isoform X2

    17. XM_047433736.1 → XP_047289692.1  WD repeat-containing protein 90 isoform X16

    18. XM_047433751.1 → XP_047289707.1  WD repeat-containing protein 90 isoform X31

    19. XM_047433726.1 → XP_047289682.1  WD repeat-containing protein 90 isoform X5

    20. XM_047433739.1 → XP_047289695.1  WD repeat-containing protein 90 isoform X19

    21. XM_047433741.1 → XP_047289697.1  WD repeat-containing protein 90 isoform X21

    22. XM_047433731.1 → XP_047289687.1  WD repeat-containing protein 90 isoform X11

    23. XM_047433752.1 → XP_047289708.1  WD repeat-containing protein 90 isoform X32

    24. XM_047433733.1 → XP_047289689.1  WD repeat-containing protein 90 isoform X13

    25. XM_047433757.1 → XP_047289713.1  WD repeat-containing protein 90 isoform X37

    26. XM_047433759.1 → XP_047289715.1  WD repeat-containing protein 90 isoform X39

    27. XM_047433742.1 → XP_047289698.1  WD repeat-containing protein 90 isoform X22

    28. XM_047433763.1 → XP_047289719.1  WD repeat-containing protein 90 isoform X43

    29. XM_017023023.2 → XP_016878512.1  WD repeat-containing protein 90 isoform X6

    30. XM_047433743.1 → XP_047289699.1  WD repeat-containing protein 90 isoform X23

    31. XM_047433754.1 → XP_047289710.1  WD repeat-containing protein 90 isoform X34

    32. XM_047433728.1 → XP_047289684.1  WD repeat-containing protein 90 isoform X8

    33. XM_047433745.1 → XP_047289701.1  WD repeat-containing protein 90 isoform X25

    34. XM_047433764.1 → XP_047289720.1  WD repeat-containing protein 90 isoform X44

    35. XM_047433748.1 → XP_047289704.1  WD repeat-containing protein 90 isoform X28

    36. XM_047433732.1 → XP_047289688.1  WD repeat-containing protein 90 isoform X12

    37. XM_047433756.1 → XP_047289712.1  WD repeat-containing protein 90 isoform X36

    38. XM_047433727.1 → XP_047289683.1  WD repeat-containing protein 90 isoform X7

    39. XM_047433729.1 → XP_047289685.1  WD repeat-containing protein 90 isoform X9

    40. XM_047433746.1 → XP_047289702.1  WD repeat-containing protein 90 isoform X26

      UniProtKB/TrEMBL
      F8VUX9
      Related
      ENSP00000448122.1, ENST00000549091.5

    41. XM_047433765.1 → XP_047289721.1  WD repeat-containing protein 90 isoform X45

    42. XM_047433755.1 → XP_047289711.1  WD repeat-containing protein 90 isoform X35

    43. XM_047433761.1 → XP_047289717.1  WD repeat-containing protein 90 isoform X41

    44. XM_047433737.1 → XP_047289693.1  WD repeat-containing protein 90 isoform X17

    45. XM_047433762.1 → XP_047289718.1  WD repeat-containing protein 90 isoform X42

    46. XM_047433766.1 → XP_047289722.1  WD repeat-containing protein 90 isoform X46

    47. XM_047433767.1 → XP_047289723.1  WD repeat-containing protein 90 isoform X47

    48. XM_047433768.1 → XP_047289724.1  WD repeat-containing protein 90 isoform X48

    49. XM_017023024.2 → XP_016878513.1  WD repeat-containing protein 90 isoform X49

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      653047..671905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379776.1 → XP_054235751.1  WD repeat-containing protein 90 isoform X24

    2. XM_054379753.1 → XP_054235728.1  WD repeat-containing protein 90 isoform X1

    3. XM_054379766.1 → XP_054235741.1  WD repeat-containing protein 90 isoform X14

    4. XM_054379755.1 → XP_054235730.1  WD repeat-containing protein 90 isoform X3

    5. XM_054379767.1 → XP_054235742.1  WD repeat-containing protein 90 isoform X15

    6. XM_054379790.1 → XP_054235765.1  WD repeat-containing protein 90 isoform X38

    7. XM_054379779.1 → XP_054235754.1  WD repeat-containing protein 90 isoform X27

    8. XM_054379781.1 → XP_054235756.1  WD repeat-containing protein 90 isoform X29

    9. XM_054379756.1 → XP_054235731.1  WD repeat-containing protein 90 isoform X4

    10. XM_054379770.1 → XP_054235745.1  WD repeat-containing protein 90 isoform X18

    11. XM_054379792.1 → XP_054235767.1  WD repeat-containing protein 90 isoform X40

    12. XM_054379772.1 → XP_054235747.1  WD repeat-containing protein 90 isoform X20

    13. XM_054379762.1 → XP_054235737.1  WD repeat-containing protein 90 isoform X10

    14. XM_054379782.1 → XP_054235757.1  WD repeat-containing protein 90 isoform X30

    15. XM_054379785.1 → XP_054235760.1  WD repeat-containing protein 90 isoform X33

    16. XM_054379754.1 → XP_054235729.1  WD repeat-containing protein 90 isoform X2

    17. XM_054379768.1 → XP_054235743.1  WD repeat-containing protein 90 isoform X16

    18. XM_054379783.1 → XP_054235758.1  WD repeat-containing protein 90 isoform X31

    19. XM_054379757.1 → XP_054235732.1  WD repeat-containing protein 90 isoform X5

    20. XM_054379771.1 → XP_054235746.1  WD repeat-containing protein 90 isoform X19

    21. XM_054379773.1 → XP_054235748.1  WD repeat-containing protein 90 isoform X21

    22. XM_054379763.1 → XP_054235738.1  WD repeat-containing protein 90 isoform X11

    23. XM_054379784.1 → XP_054235759.1  WD repeat-containing protein 90 isoform X32

    24. XM_054379765.1 → XP_054235740.1  WD repeat-containing protein 90 isoform X13

    25. XM_054379789.1 → XP_054235764.1  WD repeat-containing protein 90 isoform X37

    26. XM_054379791.1 → XP_054235766.1  WD repeat-containing protein 90 isoform X39

    27. XM_054379774.1 → XP_054235749.1  WD repeat-containing protein 90 isoform X22

    28. XM_054379795.1 → XP_054235770.1  WD repeat-containing protein 90 isoform X43

    29. XM_054379758.1 → XP_054235733.1  WD repeat-containing protein 90 isoform X6

    30. XM_054379775.1 → XP_054235750.1  WD repeat-containing protein 90 isoform X23

    31. XM_054379786.1 → XP_054235761.1  WD repeat-containing protein 90 isoform X34

    32. XM_054379760.1 → XP_054235735.1  WD repeat-containing protein 90 isoform X8

    33. XM_054379777.1 → XP_054235752.1  WD repeat-containing protein 90 isoform X25

    34. XM_054379796.1 → XP_054235771.1  WD repeat-containing protein 90 isoform X44

    35. XM_054379780.1 → XP_054235755.1  WD repeat-containing protein 90 isoform X28

    36. XM_054379764.1 → XP_054235739.1  WD repeat-containing protein 90 isoform X12

    37. XM_054379788.1 → XP_054235763.1  WD repeat-containing protein 90 isoform X36

    38. XM_054379759.1 → XP_054235734.1  WD repeat-containing protein 90 isoform X7

    39. XM_054379761.1 → XP_054235736.1  WD repeat-containing protein 90 isoform X9

    40. XM_054379778.1 → XP_054235753.1  WD repeat-containing protein 90 isoform X26

      UniProtKB/TrEMBL
      F8VUX9

    41. XM_054379797.1 → XP_054235772.1  WD repeat-containing protein 90 isoform X45

    42. XM_054379787.1 → XP_054235762.1  WD repeat-containing protein 90 isoform X35

    43. XM_054379793.1 → XP_054235768.1  WD repeat-containing protein 90 isoform X41

    44. XM_054379769.1 → XP_054235744.1  WD repeat-containing protein 90 isoform X17

    45. XM_054379794.1 → XP_054235769.1  WD repeat-containing protein 90 isoform X42

    46. XM_054379798.1 → XP_054235773.1  WD repeat-containing protein 90 isoform X46

    47. XM_054379799.1 → XP_054235774.1  WD repeat-containing protein 90 isoform X47

    48. XM_054379800.1 → XP_054235775.1  WD repeat-containing protein 90 isoform X48

    49. XM_054379801.1 → XP_054235776.1  WD repeat-containing protein 90 isoform X49

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153239.2: Suppressed sequence

      Description
      NM_153239.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96KV7.2 GenPept UniProtKB/Swiss-Prot:Q96KV7

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