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    CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 [ Homo sapiens (human) ]

    Gene ID: 59283, updated on 9-Dec-2024

    Summary

    Official Symbol
    CACNG8provided by HGNC
    Official Full Name
    calcium voltage-gated channel auxiliary subunit gamma 8provided by HGNC
    Primary source
    HGNC:HGNC:13628
    See related
    Ensembl:ENSG00000142408 MIM:606900; AllianceGenome:HGNC:13628
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]
    Expression
    Restricted expression toward brain (RPKM 9.1) See more
    Orthologs
    NEW
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    Genomic context

    See CACNG8 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53962937..53990215)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57041427..57068705)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54466191..54493469)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54385903-54386454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54395841-54396380 Neighboring gene Sharpr-MPRA regulatory region 4174 Neighboring gene protein kinase C gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54410617-54411158 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7 Neighboring gene MPRA-validated peak3551 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54460576-54461110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54463321-54464221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54465032-54465552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54483237-54483769 Neighboring gene microRNA 935 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 6 Neighboring gene Sharpr-MPRA regulatory region 12456 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54526043-54526246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54539139-54539714 Neighboring gene V-set and transmembrane domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16240, FLJ30598

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated calcium channel activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in neurotransmitter receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of AMPA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmission of nerve impulse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of AMPA glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of L-type voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated calcium channel complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    voltage-dependent calcium channel gamma-8 subunit
    Names
    TARP gamma-8
    calcium channel, voltage-dependent, gamma subunit 8
    neuronal voltage-gated calcium channel gamma-8 subunit
    transmembrane AMPAR regulatory protein gamma-8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031895.6NP_114101.4  voltage-dependent calcium channel gamma-8 subunit

      See identical proteins and their annotated locations for NP_114101.4

      Status: REVIEWED

      Source sequence(s)
      AC008440, AF288388
      Consensus CDS
      CCDS33104.1
      UniProtKB/Swiss-Prot
      Q8WXS5, Q9BXT0, Q9BY23
      UniProtKB/TrEMBL
      A0A1X7SBR8
      Related
      ENSP00000270458.3, ENST00000270458.4
      Conserved Domains (1) summary
      cl21598
      Location:17223
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53962937..53990215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57041427..57068705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)