PRDM16-DT PRDM16 divergent transcript [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRDM16-DTprovided by HGNC
Official Full Name: PRDM16 divergent transcriptprovided by HGNC
Primary source: HGNC:HGNC:48664
See related: Ensembl:ENSG00000177133 AllianceGenome:HGNC:48664
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINC00982; lnc-dPrdm16
Expression: Biased expression in kidney (RPKM 17.6), stomach (RPKM 7.0) and 5 other tissues See more
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Genomic context

Location:: 1p36.32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (3059617..3067725, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (2561659..2569767, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (2976181..2984289, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
Title: LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro.
Title: LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro.
LINC00982 Inhibits the Proliferation, Migration, and Invasion of Breast Cancer Cells Through the miR-765/DPF3 Axis.
Title: LINC00982 Inhibits the Proliferation, Migration, and Invasion of Breast Cancer Cells Through the miR-765/DPF3 Axis.
Overexpression of LINC00982 inhibited proliferation and promoted apoptosis and regulate the activity of PI3K/AKT signaling pathway.
Title: Upregulation of LINC00982 inhibits cell proliferation and promotes cell apoptosis by regulating the activity of PI3K/AKT signaling pathway in renal cancer.
Study revealed that LINC00982 and PRDM16 may serve as biomarkers or potential drug targets for the diagnosis and therapy of lung adenocarcinoma.
Title: Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma.
Our findings present that decreased lncRNA LINC00982 could be identified as a poor prognostic biomarker in gastric cancer and regulate cell proliferation.
Title: Upregulated expression of long non-coding RNA LINC00982 regulates cell proliferation and its clinical relevance in patients with gastric cancer.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74131 (e-PCR)
- UniSTS:39448

D1S1828E (e-PCR)
- UniSTS:150831

SHGC-74108 (e-PCR)
- UniSTS:65909

D1S1446 (e-PCR)
- UniSTS:149642

D1S3023 (e-PCR)
- UniSTS:16889

Other Names

long intergenic non-protein coding RNA 982

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_015440.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AL713743, AL832943, BC029785, BM931404

Related

ENST00000445317.1
NR_024371.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' end compared to variant 1.

Source sequence(s)

BC029785, BM931404

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

3059617..3067725 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

2561659..2569767 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001004337.1: Suppressed sequence

Description

NM_001004337.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
NM_198543.1: Suppressed sequence

Description

NM_198543.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.