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    KLHL34 kelch like family member 34 [ Homo sapiens (human) ]

    Gene ID: 257240, updated on 27-Nov-2024

    Summary

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    Official Symbol
    KLHL34provided by HGNC
    Official Full Name
    kelch like family member 34provided by HGNC
    Primary source
    HGNC:HGNC:26634
    See related
    Ensembl:ENSG00000185915 AllianceGenome:HGNC:26634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    mouse all
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    Genomic context

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    See KLHL34 in Genome Data Viewer
    Location:
    Xp22.12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (21654690..21658330, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (21238012..21241652, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (21672808..21676448, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:21357913-21358412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:21391460-21391960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:21391961-21392461 Neighboring gene connector enhancer of kinase suppressor of Ras 2 Neighboring gene retinoic acid receptor responder 2 pseudogene 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:21704726-21705925 Neighboring gene small muscle protein X-linked Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29486 Neighboring gene membrane bound transcription factor peptidase, site 2 Neighboring gene YY2 transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Update on the Kelch-like (KLHL) gene family. Dhanoa BS, et al. Hum Genomics, 2013 May 15. PMID 23676014, Free PMC Article
    2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article
    4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34960, MGC125650

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    kelch-like protein 34
    Names
    RP11-450P7.3
    kelch-like 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153270.3 → NP_695002.1  kelch-like protein 34

      See identical proteins and their annotated locations for NP_695002.1

      Status: VALIDATED

      Source sequence(s)
      AI792176, AL772392, BC109031, DA395149
      Consensus CDS
      CCDS14199.1
      UniProtKB/Swiss-Prot
      Q8N239
      Related
      ENSP00000368813.2, ENST00000379499.3
      Conserved Domains (3) summary
      sd00038
      Location:358 → 411
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:19 → 126
      BTB; BTB/POZ domain
      cl28614
      Location:29 → 603
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      21654690..21658330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      21238012..21241652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N239.1 GenPept UniProtKB/Swiss-Prot:Q8N239

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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