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    MMP15 matrix metallopeptidase 15 [ Homo sapiens (human) ]

    Gene ID: 4324, updated on 9-Dec-2024

    Summary

    Official Symbol
    MMP15provided by HGNC
    Official Full Name
    matrix metallopeptidase 15provided by HGNC
    Primary source
    HGNC:HGNC:7161
    See related
    Ensembl:ENSG00000102996 MIM:602261; AllianceGenome:HGNC:7161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MMP-15; MT2MMP; MTMMP2; SMCP-2; MT2-MMP
    Summary
    This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in thyroid (RPKM 28.2), placenta (RPKM 20.0) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MMP15 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (58025754..58046901)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63821030..63842175)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58059658..58080805)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10918 Neighboring gene sperm microtubule inner protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7540 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43822 Neighboring gene Sharpr-MPRA regulatory region 3942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10920 Neighboring gene zinc finger protein 319 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58046115-58046647 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58046648-58047179 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58058267-58058854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58058855-58059440 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58059673-58060222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58060773-58061322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58119688-58120378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58131910-58132410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58132411-58132911 Neighboring gene TIPIN pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58162549-58163470 Neighboring gene uncharacterized LOC101927556 Neighboring gene cilia and flagella associated protein 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metalloaminopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in collagen catabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in endodermal cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-15
    Names
    MT-MMP 2
    matrix metallopeptidase 15 (membrane-inserted)
    matrix metalloproteinase 15 (membrane-inserted)
    membrane-type matrix metalloproteinase 2
    membrane-type-2 matrix metalloproteinase
    NP_002419.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002428.4NP_002419.1  matrix metalloproteinase-15 preproprotein

      See identical proteins and their annotated locations for NP_002419.1

      Status: REVIEWED

      Source sequence(s)
      AW161057, BC006412, BC055428, Z48482
      Consensus CDS
      CCDS10792.1
      UniProtKB/Swiss-Prot
      A0A2U6, P51511, Q14111
      UniProtKB/TrEMBL
      Q7KZY0
      Related
      ENSP00000219271.3, ENST00000219271.4
      Conserved Domains (5) summary
      cd00094
      Location:367559
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:138304
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:138304
      Peptidase_M10; Matrixin
      pfam01471
      Location:53106
      PG_binding_1; Putative peptidoglycan binding domain
      pfam11857
      Location:644669
      DUF3377; Domain of unknown function (DUF3377)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      58025754..58046901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63821030..63842175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)