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    POLR3G RNA polymerase III subunit G [ Homo sapiens (human) ]

    Gene ID: 10622, updated on 10-Dec-2024

    Summary

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    Official Symbol
    POLR3Gprovided by HGNC
    Official Full Name
    RNA polymerase III subunit Gprovided by HGNC
    Primary source
    HGNC:HGNC:30075
    See related
    Ensembl:ENSG00000113356 MIM:617456; AllianceGenome:HGNC:30075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C31; RPC7; RPC32
    Summary
    Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 1.8), esophagus (RPKM 1.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See POLR3G in Genome Data Viewer
    Location:
    5q14.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (90473929..90514557)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (90960487..91001143)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (89769746..89810374)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16167 Neighboring gene uncharacterized LOC731157 Neighboring gene centrin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22779 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:89820083-89820584 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:89824672-89825172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22780 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:89838485-89839226 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89850082-89850882 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89853234-89853735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16170 Neighboring gene LysM domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:89900954-89901152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22781 Neighboring gene adhesion G protein-coupled receptor V1 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89940736-89941239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:89963673-89964204 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89968220-89968777 Neighboring gene uncharacterized LOC105379077 Neighboring gene NANOG hESC enhancer GRCh37_chr5:90033573-90034074

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer. Chen H, et al. FASEB J, 2023 Dec. PMID 37933949
    2. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA(+) and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Lund RJ, et al. Stem Cell Reports, 2017 May 9. PMID 28494942, Free PMC Article
    3. Effects on prostate cancer cells of targeting RNA polymerase III. Petrie JL, et al. Nucleic Acids Res, 2019 May 7. PMID 30820548, Free PMC Article
    4. Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. Chantarangsu S, et al. Clin Infect Dis, 2011 Aug. PMID 21810746
    5. A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Wong RC, et al. Stem Cells, 2011 Oct. PMID 21898682

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer.
      Title: POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer.
    2. A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.
      Title: A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.
    3. RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination.
      Title: RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination.
    4. FCER1A (rs7549785) and possibly POLR3G (rs7712322) are shown to be associated with peginterferon alfa-2a response in adult patients with chronic hepatitis B.
      Title: Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B.
    5. Depletion of POLR3G selectively triggers proliferative arrest and differentiation of prostate cancer cells, responses not elicited when POLR3GL is depleted.
      Title: Effects on prostate cancer cells of targeting RNA polymerase III.
    6. POLR3G regulates small non-coding RNAs and RNA splicing in human pluripotent stem cells. The primary function of POLR3G is in the maintenance rather than repression of transcription.
      Title: RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA(+) and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells.
    7. Decreased levels of POLR3G result in loss of pluripotency and promote differentiation of human embryonic stem cells to all three germ layers but have no effect on cell apoptosis.
      Title: A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell population proliferation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase III TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC7
    Names
    DNA-directed RNA polymerase III 32 kDa polypeptide
    DNA-directed RNA polymerase III subunit G
    RNA polymerase III 32 kDa apha subunit
    RNA polymerase III 32 kDa subunit
    RNA polymerase III subunit C7
    RPC32-alpha
    polymerase (RNA) III (DNA directed) polypeptide G (32kD)
    polymerase (RNA) III subunit G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370351.1 → NP_001357280.1  DNA-directed RNA polymerase III subunit RPC7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC027323, AC093510
      Consensus CDS
      CCDS43337.1
      UniProtKB/Swiss-Prot
      A8MTH0, O15318
      UniProtKB/TrEMBL
      D6R9U7
      Related
      ENSP00000421637.1, ENST00000504930.5
      Conserved Domains (1) summary
      pfam11705
      Location:5 → 209
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    2. NM_001370352.1 → NP_001357281.1  DNA-directed RNA polymerase III subunit RPC7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC027323, AC093510
      UniProtKB/TrEMBL
      D6R9U7
      Conserved Domains (1) summary
      pfam11705
      Location:5 → 208
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    3. NM_001370353.1 → NP_001357282.1  DNA-directed RNA polymerase III subunit RPC7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC027323, AC093510
      UniProtKB/TrEMBL
      D6R9U7
      Conserved Domains (1) summary
      pfam11705
      Location:5 → 208
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    4. NM_001370354.1 → NP_001357283.1  DNA-directed RNA polymerase III subunit RPC7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC027323, AC093510
      Consensus CDS
      CCDS43337.1
      UniProtKB/Swiss-Prot
      A8MTH0, O15318
      UniProtKB/TrEMBL
      D6R9U7
      Related
      ENSP00000422892.1, ENST00000503373.5
      Conserved Domains (1) summary
      pfam11705
      Location:5 → 209
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    5. NM_006467.3 → NP_006458.2  DNA-directed RNA polymerase III subunit RPC7 isoform 1

      See identical proteins and their annotated locations for NP_006458.2

      Status: VALIDATED

      Source sequence(s)
      AC027323, BM788728, BP348952, CD657312
      Consensus CDS
      CCDS43337.1
      UniProtKB/Swiss-Prot
      A8MTH0, O15318
      UniProtKB/TrEMBL
      D6R9U7
      Related
      ENSP00000498469.1, ENST00000651687.1
      Conserved Domains (1) summary
      pfam11705
      Location:5 → 209
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      90473929..90514557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416634.1 → XP_047272590.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      UniProtKB/TrEMBL
      D6R9U7

    2. XM_011543101.4 → XP_011541403.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      See identical proteins and their annotated locations for XP_011541403.1

      UniProtKB/Swiss-Prot
      A8MTH0, O15318
      UniProtKB/TrEMBL
      D6R9U7
      Conserved Domains (1) summary
      pfam11705
      Location:5 → 209
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    3. XM_047416635.1 → XP_047272591.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      UniProtKB/TrEMBL
      D6R9U7

    4. XM_017008957.3 → XP_016864446.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      UniProtKB/Swiss-Prot
      A8MTH0, O15318
      UniProtKB/TrEMBL
      D6R9U7
      Conserved Domains (1) summary
      pfam11705
      Location:5 → 209
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    5. XM_047416633.1 → XP_047272589.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      UniProtKB/TrEMBL
      D6R9U7

    6. XM_047416637.1 → XP_047272593.1  DNA-directed RNA polymerase III subunit RPC7 isoform X4

    7. XM_047416636.1 → XP_047272592.1  DNA-directed RNA polymerase III subunit RPC7 isoform X3

      UniProtKB/TrEMBL
      A0A7I2R591
      Related
      ENSP00000382058.2, ENST00000399107.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      90960487..91001143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351445.1 → XP_054207420.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      UniProtKB/TrEMBL
      D6R9U7

    2. XM_054351443.1 → XP_054207418.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      UniProtKB/Swiss-Prot
      A8MTH0, O15318
      UniProtKB/TrEMBL
      D6R9U7

    3. XM_054351446.1 → XP_054207421.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      UniProtKB/TrEMBL
      D6R9U7

    4. XM_054351442.1 → XP_054207417.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      UniProtKB/Swiss-Prot
      A8MTH0, O15318
      UniProtKB/TrEMBL
      D6R9U7

    5. XM_054351444.1 → XP_054207419.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      UniProtKB/TrEMBL
      D6R9U7

    6. XM_054351448.1 → XP_054207423.1  DNA-directed RNA polymerase III subunit RPC7 isoform X4

    7. XM_054351447.1 → XP_054207422.1  DNA-directed RNA polymerase III subunit RPC7 isoform X3

      UniProtKB/TrEMBL
      A0A7I2R591
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15318.2 GenPept UniProtKB/Swiss-Prot:O15318

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