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    SNTN sentan, cilia apical structure protein [ Homo sapiens (human) ]

    Gene ID: 132203, updated on 10-Dec-2024

    Summary

    Official Symbol
    SNTNprovided by HGNC
    Official Full Name
    sentan, cilia apical structure proteinprovided by HGNC
    Primary source
    HGNC:HGNC:33706
    See related
    Ensembl:ENSG00000188817 MIM:617832; AllianceGenome:HGNC:33706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S100AL; sentan; S100A1L
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward lung (RPKM 7.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SNTN in Genome Data Viewer
    Location:
    3p14.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (63652675..63665212)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (63696298..63708831)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (63638351..63650888)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ubiquitin like 5 pseudogene 3 Neighboring gene synaptoporin Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:63329277-63329919 Neighboring gene NANOG hESC enhancer GRCh37_chr3:63429870-63430414 Neighboring gene SYNPR antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 134 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:63562463-63562990 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:63631069-63631622 Neighboring gene NANOG hESC enhancer GRCh37_chr3:63637673-63638197 Neighboring gene VISTA enhancer hs1387 Neighboring gene uncharacterized LOC105377119 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:63718649-63719284 Neighboring gene cadherin related family member 18, pseudogene Neighboring gene chromosome 3 open reading frame 49

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Markers

    Clone Names

    • FLJ44379

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sentan
    Names
    S100A-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080537.2NP_001074006.1  sentan isoform 2

      See identical proteins and their annotated locations for NP_001074006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC136289
      Consensus CDS
      CCDS33779.1
      UniProtKB/Swiss-Prot
      A6NMZ2, B7FF65
      UniProtKB/TrEMBL
      C9JRU3
      Related
      ENSP00000341442.3, ENST00000343837.8
      Conserved Domains (1) summary
      cd00213
      Location:54138
      S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
    2. NM_001348756.2NP_001335685.1  sentan isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC136289
      UniProtKB/TrEMBL
      C9JRU3
      Related
      ENSP00000420078.1, ENST00000469440.5
      Conserved Domains (1) summary
      cd00213
      Location:54168
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      63652675..63665212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      63696298..63708831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)