Uckl1 uridine-cytidine kinase 1-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uckl1provided by MGI
Official Full Name: uridine-cytidine kinase 1-like 1provided by MGI
Primary source: MGI:MGI:1915806
See related: Ensembl:ENSMUSG00000089917 AllianceGenome:MGI:1915806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Urkl1; 1110007H10Rik
Summary: Predicted to enable ATP binding activity; cytidine kinase activity; and uridine kinase activity. Predicted to be involved in CMP biosynthetic process and UMP salvage. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 15.0), thymus adult (RPKM 14.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.66 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (181210942..181223820, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (181569149..181582027, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer.
Title: Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	IEA Inferred from Electronic Annotation more info
enables uridine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uridine-cytidine kinase-like 1

Names: uridine kinase-like 1

NP_001365934.1

EC 2.7.1.48

NP_081041.2

EC 2.7.1.48

XP_006500767.1

EC 2.7.1.48

XP_006500768.1

EC 2.7.1.48

XP_006500769.1

EC 2.7.1.48

XP_006500772.1

EC 2.7.1.48

XP_006500773.1

EC 2.7.1.48

XP_011238262.1

EC 2.7.1.48

XP_030107893.1

EC 2.7.1.48

XP_030107894.1

EC 2.7.1.48

XP_030107895.1

EC 2.7.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379005.1 → NP_001365934.1 uridine-cytidine kinase-like 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL844529

Conserved Domains (2) summary

cd02023
Location:101 → 299

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:330 → 533

UPRTase; Uracil phosphoribosyltransferase
NM_026765.3 → NP_081041.2 uridine-cytidine kinase-like 1 isoform 2

See identical proteins and their annotated locations for NP_081041.2

Status: VALIDATED

Source sequence(s)

AL844529

Consensus CDS

CCDS17216.1

UniProtKB/Swiss-Prot

Q91YL3

Related

ENSMUSP00000050398.9, ENSMUST00000057816.15

Conserved Domains (3) summary

COG0572
Location:93 → 306

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:101 → 299

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:329 → 532

UPRTase; Uracil phosphoribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

181210942..181223820 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500709.4 → XP_006500772.1 uridine-cytidine kinase-like 1 isoform X7

See identical proteins and their annotated locations for XP_006500772.1

Conserved Domains (2) summary

cd02023
Location:1 → 183

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:214 → 417

UPRTase; Uracil phosphoribosyltransferase
XM_030252033.1 → XP_030107893.1 uridine-cytidine kinase-like 1 isoform X1

Conserved Domains (2) summary

cd02023
Location:100 → 298

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:329 → 532

UPRTase; Uracil phosphoribosyltransferase
XM_030252034.1 → XP_030107894.1 uridine-cytidine kinase-like 1 isoform X2

Conserved Domains (2) summary

cd02023
Location:100 → 298

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:328 → 531

UPRTase; Uracil phosphoribosyltransferase
XM_006500704.4 → XP_006500767.1 uridine-cytidine kinase-like 1 isoform X3

Conserved Domains (2) summary

cd02023
Location:86 → 284

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:315 → 518

UPRTase; Uracil phosphoribosyltransferase
XM_006500705.4 → XP_006500768.1 uridine-cytidine kinase-like 1 isoform X4

Conserved Domains (2) summary

cd02023
Location:86 → 284

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:314 → 517

UPRTase; Uracil phosphoribosyltransferase
XM_006500706.5 → XP_006500769.1 uridine-cytidine kinase-like 1 isoform X5

Conserved Domains (2) summary

cd02023
Location:85 → 283

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:314 → 517

UPRTase; Uracil phosphoribosyltransferase
XM_030252035.2 → XP_030107895.1 uridine-cytidine kinase-like 1 isoform X6

Conserved Domains (2) summary

cd02023
Location:85 → 283

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:313 → 516

UPRTase; Uracil phosphoribosyltransferase
XM_006500710.5 → XP_006500773.1 uridine-cytidine kinase-like 1 isoform X7

See identical proteins and their annotated locations for XP_006500773.1

Conserved Domains (2) summary

cd02023
Location:1 → 183

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:214 → 417

UPRTase; Uracil phosphoribosyltransferase
XM_011239960.3 → XP_011238262.1 uridine-cytidine kinase-like 1 isoform X8

Conserved Domains (2) summary

pfam14681
Location:109 → 312

UPRTase; Uracil phosphoribosyltransferase

cl17190
Location:1 → 78

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...