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    ufd2 ubiquitin-protein ligase E4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542023, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ufd2
    Official Full Name
    ubiquitin-protein ligase E4
    Primary source
    PomBase:SPAC20H4.10
    Locus tag
    SPOM_SPAC20H4.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ufd2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (2128441..2131713)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphatase activator Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rho family GTPase Rho5 Neighboring gene ncRNA Neighboring gene family protein ICE2 Neighboring gene 40S ribosomal protein uS12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast. Gatti L, et al. BMC Genomics, 2011 Jan 19. PMID 21247416, Free PMC Article
    2. Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase. Jang YJ, et al. Yeast, 2013 Oct. PMID 23640764
    3. The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain. Hänzelmann P, et al. J Biol Chem, 2010 Jun 25. PMID 20427284, Free PMC Article
    4. Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe. Xu X, et al. G3 (Bethesda), 2018 Mar 2. PMID 29352077, Free PMC Article
    5. A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast. Paul SK, et al. FEBS J, 2009 Sep. PMID 19682301

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ufd2 induces cell death in prolonged nutrient deprivation, that Sds23/Psp1/Moc1 may be a target protein of the ubiquitin-fusion degradation pathway for regulation of cell viability under this stress condition.
      Title: Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.
    2. Data show that ufd2 mutants exhibiting resistance to cisplatin.
      Title: Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-protein ligase E4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2128441..2131713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019061.3 → NP_593630.1  ubiquitin-protein ligase E4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593630.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60009, Q9HE05, Q9P7A3, Q9UTT4, Q9UU63
      Conserved Domains (3) summary
      COG5113
      Location:76 → 1010
      UFD2; Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]
      pfam04564
      Location:931 → 1003
      U-box; U-box domain
      pfam10408
      Location:290 → 914
      Ufd2P_core; Ubiquitin elongating factor core
    Nucleotide Protein
    Heading Accession and Version

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