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    myp2 Myo3-like myosin II heavy chain myp2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543576, updated on 5-Jan-2025

    Summary

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    Official Symbol
    myp2
    Official Full Name
    Myo3-like myosin II heavy chain myp2
    Primary source
    PomBase:SPAC4A8.05c
    Locus tag
    SPOM_SPAC4A8.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    myo3
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    Genomic context

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    See myp2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2547260..2553703, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar serine protease Isp6 Neighboring gene ncRNA Neighboring gene esterase/lipase Neighboring gene ncRNA Neighboring gene sphinganine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis. Malla M, et al. Mol Biol Cell, 2022 May 15. PMID 34613787, Free PMC Article
    2. Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast. Fujita M, et al. Genetics, 2002 Jul. PMID 12136004, Free PMC Article
    3. Motor Activity Dependent and Independent Functions of Myosin II Contribute to Actomyosin Ring Assembly and Contraction in Schizosaccharomyces pombe. Palani S, et al. Curr Biol, 2017 Mar 6. PMID 28238661, Free PMC Article
    4. In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics. Mishra M, et al. Nat Cell Biol, 2013 Jul. PMID 23770677
    5. Myosin-II tails confer unique functions in Schizosaccharomyces pombe: characterization of a novel myosin-II tail. Bezanilla M, et al. Mol Biol Cell, 2000 Jan. PMID 10637292, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We provide evidence that the myosin II protein Myp2 and the myosin V protein Myo51 play roles in recruiting TORC2 to the CAR.We go on to show that TORC2-dependent phosphorylation of actin-capping protein 1 (Acp1, a known regulator of cytokinesis) controls CAR stability, modulates Acp1-Acp2 heterodimer formation and is essential for survival upon stress.
      Title: TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.
    2. Three myosins function in a hierarchal, complementary manner to accomplish cytokinesis, with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest contribution to constriction.
      Title: Three myosins contribute uniquely to the assembly and constriction of the fission yeast cytokinetic contractile ring.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration during mitotic telophase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin ring complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, proximal layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Myo3-like myosin II heavy chain myp2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2547260..2553703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019246.3 → NP_593816.1  Myo3-like myosin II heavy chain myp2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593816.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14157, O42730, Q9UU49
      Conserved Domains (5) summary
      COG5022
      Location:17 → 1607
      COG5022; Myosin heavy chain [General function prediction only]
      cd01377
      Location:103 → 755
      MYSc_class_II; class II myosins, motor domain
      pfam02736
      Location:38 → 76
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam08581
      Location:1684 → 1759
      Tup_N; Tup N-terminal
      cl23720
      Location:1997 → 2072
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version

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