U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cdc6 DNA polymerase delta catalytic subunit Cdc6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540255, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cdc6
    Official Full Name
    DNA polymerase delta catalytic subunit Cdc6
    Primary source
    PomBase:SPBC336.04
    Locus tag
    SPOM_SPBC336.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mis10; pol3; pold
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cdc6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2743762..2748596)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ras guanine nucleotide exchange factor efc25 Neighboring gene ncRNA Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribonuclease H Rnh1 Neighboring gene transcription factor TFIIIC subunit Sfc3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit. Sanchez Garcia J, et al. Nucleic Acids Res, 2004. PMID 15173383, Free PMC Article
    2. Expression of the catalytic subunits of pol alpha and pol delta from fission yeast Schizosaccharomyces pombe. Pignède G, et al. Chromosoma, 1992. PMID 1291234
    3. A global profile of replicative polymerase usage. Daigaku Y, et al. Nat Struct Mol Biol, 2015 Mar. PMID 25664722, Free PMC Article
    4. PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast. Daigaku Y, et al. PLoS Genet, 2017 May. PMID 28481910, Free PMC Article
    5. Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis. Sanchez Garcia J, et al. BMC Mol Biol, 2009 Aug 17. PMID 19686603, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication proofreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA strand elongation involved in mitotic DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA synthesis involved in UV-damage excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair, gap-filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication lagging strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of delta DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA polymerase delta catalytic subunit Cdc6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2743762..2748596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022042.3 → NP_596124.1  DNA polymerase delta catalytic subunit Cdc6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596124.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P30316, Q10016, Q9USU0, Q9UU61
      Conserved Domains (4) summary
      cd05777
      Location:288 → 517
      DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
      cd05533
      Location:564 → 957
      POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
      PTZ00166
      Location:85 → 1083
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:993 → 1064
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.