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    SRB5 Srb5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRB5
    Official Full Name
    Srb5p
    Primary source
    SGD:S000003336
    Locus tag
    YGR104C
    See related
    AllianceGenome:SGD:S000003336; FungiDB:YGR104C; VEuPathDB:YGR104C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED18
    Summary
    Enables RNA polymerase II core promoter sequence-specific DNA binding activity and transcription coactivator activity. Involved in cellular response to heat; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRB5 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (697445..698368, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit F Neighboring gene mRNA-binding ribosome synthesis protein NOP7 Neighboring gene Vma21p Neighboring gene Voa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel role for mediator complex subunit Srb5/Med18 in termination of transcription. Mukundan B, et al. J Biol Chem, 2011 Oct 28. PMID 21921038, Free PMC Article
    2. Med8, Med18, and Med20 subunits of the Mediator head domain are interdependent upon each other for folding and complex formation. Adler D, et al. Proc Natl Acad Sci U S A, 2009 Dec 8. PMID 19934057, Free PMC Article
    3. Activation of a poised RNAPII-dependent promoter requires both SAGA and mediator. Lee SK, et al. Genetics, 2010 Mar. PMID 20048049, Free PMC Article
    4. Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme. Gaudreau L, et al. Mol Cell, 1998 May. PMID 9660974
    5. Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Larivière L, et al. Nat Struct Mol Biol, 2006 Oct. PMID 16964259

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gene looping plays a crucial role in Srb5/Med18 facilitated termination of transcription, and the looped gene architecture may have a general role in termination of transcription in budding yeast.
      Title: Srb5/Med18-mediated termination of transcription is dependent on gene looping.
    2. Mediator subunit Srb5/Med18 is required for proper termination of transcription of a subset of genes in budding yeast.
      Title: Novel role for mediator complex subunit Srb5/Med18 in termination of transcription.
    3. Our results and published data support a positive role of the Med8/18/20 subcomplex in initiation-complex formation and suggest that the Mediator head contains a multipartite TBP-binding site that can be modulated by transcriptional activators.
      Title: Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription open complex formation at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Srb5p
    NP_011618.3
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      697445..698368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181233.3 → NP_011618.3  TPA: Srb5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011618.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUN6, P32585, Q6B1R3
      UniProtKB/TrEMBL
      B3LIC2, B5VJ51, C7GWV9, C8Z8Z7
      Conserved Domains (1) summary
      pfam09637
      Location:3 → 299
      Med18; Med18 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32585.1

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