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    prp4 serine/threonine protein kinase Prp4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539312, updated on 18-Sep-2024

    Summary

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    Official Symbol
    prp4
    Official Full Name
    serine/threonine protein kinase Prp4
    Primary source
    PomBase:SPCC777.14
    Locus tag
    SPOM_SPCC777.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See prp4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1622499..1624475)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene retromer complex subunit Vps35 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA dihydrouridine synthase Dus4 Neighboring gene protein phosphatase regulatory subunit Ekc1 Neighboring gene ncRNA Neighboring gene wtf element Wtf14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation. Eckert D, et al. PLoS Genet, 2016 Jan. PMID 26730850, Free PMC Article
    2. Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe. Pozgajova M, et al. Acta Biochim Pol, 2013. PMID 24432349
    3. The prp1+ gene required for pre-mRNA splicing in Schizosaccharomyces pombe encodes a protein that contains TPR motifs and is similar to Prp6p of budding yeast. Urushiyama S, et al. Genetics, 1997 Sep. PMID 9286671, Free PMC Article
    4. Identification and characterization of srp1, a gene of fission yeast encoding a RNA binding domain and a RS domain typical of SR splicing factors. Gross T, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421507, Free PMC Article
    5. Fission yeast Prp4p kinase regulates pre-mRNA splicing by phosphorylating a non-SR-splicing factor. Schwelnus W, et al. EMBO Rep, 2001 Jan. PMID 11252721, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase Prp4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1622499..1624475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023251.3 → NP_588261.1  serine/threonine protein kinase Prp4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588261.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87202, Q07538
      Conserved Domains (2) summary
      smart00220
      Location:159 → 474
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:158 → 474
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
    Nucleotide Protein
    Heading Accession and Version

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