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    mtl1 exosome RNA helicase subunit Mtl1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542173, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mtl1
    Official Full Name
    exosome RNA helicase subunit Mtl1
    Primary source
    PomBase:SPAC17H9.02
    Locus tag
    SPOM_SPAC17H9.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mtl1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2004706..2008108)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene poly(A) polymerase Cid16 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RAD51D-like protein 1 Neighboring gene RNA-binding protein involved in heterochromatin assembly Dri1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex. Foucher AE, et al. Nat Commun, 2022 Aug 24. PMID 36002457, Free PMC Article
    2. Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation. Mikolaskova B, et al. Int J Mol Sci, 2021 Jun 29. PMID 34209806, Free PMC Article
    3. The RNA exosome promotes transcription termination of backtracked RNA polymerase II. Lemay JF, et al. Nat Struct Mol Biol, 2014 Oct. PMID 25240800
    4. Ubiquitination-dependent control of sexual differentiation in fission yeast. Simonetti F, et al. Elife, 2017 Aug 25. PMID 28841135, Free PMC Article
    5. The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome. Zhou Y, et al. Nat Commun, 2015 May 20. PMID 25989903, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance of spliceosomal pre-mRNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in siRNA-independent facultative heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sno(s)RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MTREC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT part_of TRAMP complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in heterochromatin island IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    exosome RNA helicase subunit Mtl1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2004706..2008108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019004.3 → NP_593572.1  exosome RNA helicase subunit Mtl1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593572.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13799
      Conserved Domains (5) summary
      COG4581
      Location:5 → 1030
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      cd00079
      Location:358 → 522
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:128 → 277
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:855 → 1023
      DSHCT; DSHCT (NUC185) domain
      pfam13234
      Location:568 → 826
      rRNA_proc-arch; rRNA-processing arch domain
    Nucleotide Protein
    Heading Accession and Version

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