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    atb2 tubulin alpha 2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540936, updated on 18-Sep-2024

    Summary

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    Official Symbol
    atb2
    Official Full Name
    tubulin alpha 2
    Primary source
    PomBase:SPBC800.05c
    Locus tag
    SPOM_SPBC800.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    alp2; ban5; tub1
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    Genomic context

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    See atb2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (260309..262116, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL43 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribosome biogenesis protein brx1 Neighboring gene ncRNA Neighboring gene translation elongation factor EF-Ts Tsf1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubules mediate mitochondrial distribution in fission yeast. Yaffe MP, et al. Proc Natl Acad Sci U S A, 1996 Oct 15. PMID 8876193, Free PMC Article
    2. The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis. Hiraoka Y, et al. Cell, 1984 Dec. PMID 6094012
    3. The Schizosaccharomyces pombe EB1 homolog Mal3p binds and stabilizes the microtubule lattice seam. Sandblad L, et al. Cell, 2006 Dec 29. PMID 17190604
    4. Nuclear shape, growth and integrity in the closed mitosis of fission yeast depend on the Ran-GTPase system, the spindle pole body and the endoplasmic reticulum. Gonzalez Y, et al. J Cell Sci, 2009 Jul 15. PMID 19571115, Free PMC Article
    5. pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast. Matsuyama A, et al. Yeast, 2004 Nov. PMID 15546162

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel temperature-sensitive mutant of fission yeast alpha-tubulin Atb2 (atb2-983) displays a high rate of chromosome missegregation and is synthetically lethal with deletions in a subset of spindle checkpoint genes including bub1.
      Title: The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion distribution EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitochondrion distribution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration by microtubule mediated pushing forces IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration by microtubule mediated pushing forces IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in astral microtubule NAS
    Non-traceable Author Statement
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin alpha 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      260309..262116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021013.3 → NP_595106.1  tubulin alpha 2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595106.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P04689, Q9HGL7
      Conserved Domains (2) summary
      PTZ00335
      Location:1 → 448
      PTZ00335; tubulin alpha chain; Provisional
      cd02186
      Location:2 → 435
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein
    Heading Accession and Version

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