MDM10 Mdm10p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MDM10
Official Full Name: Mdm10p
Primary source: SGD:S000000008
Locus tag: YAL010C
See related: AllianceGenome:SGD:S000000008; FungiDB:YAL010C; VEuPathDB:YAL010C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FUN37
Summary: Involved in several processes, including establishment of mitochondrion localization; mitochondrion-endoplasmic reticulum membrane tethering; and outer mitochondrial membrane organization. Located in mitochondrial outer membrane. Part of ERMES complex and SAM complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MDM10 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (134184..135665, complement)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex
Title: Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40.
Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex
Title: Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40.
Tom7-mediated segregation of Mdm10 functions by a differentiation of beta-barrel assembly
Title: Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in establishment of mitochondrion localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial outer membrane translocase complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial outer membrane translocase complex assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial outer membrane translocase complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial outer membrane translocase complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion-endoplasmic reticulum membrane tethering	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein insertion into mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ERMES complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ERMES complex	IEA Inferred from Electronic Annotation more info
part_of ERMES complex	IPI Inferred from Physical Interaction more info	PubMed
part_of SAM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAM complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mdm10p

NP_009392.2

Moonlighting protein component of both the ERMES and SAM complex; subunit of the ERMES complex that acts as a molecular tether between the mitochondria and the ER, necessary for both efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex subunit that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex often co-localizes with peroxisomes adjacent to mitochondria-ER junctions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

134184..135665 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178155.2 → NP_009392.2 TPA: Mdm10p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009392.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A7A0F9, D6VPK8, P18409

UniProtKB/TrEMBL

N1PAZ3

Conserved Domains (1) summary

pfam12519
Location:1 → 493

MDM10; Mitochondrial distribution and morphology protein 10