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    STS1 Sts1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854828, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STS1
    Official Full Name
    Sts1p
    Primary source
    SGD:S000001450
    Locus tag
    YIR011C
    See related
    AllianceGenome:SGD:S000001450; FungiDB:YIR011C; VEuPathDB:YIR011C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DBF8; SSM5
    Summary
    Enables proteasome binding activity. Involved in chromosome segregation; nuclear protein quality control by the ubiquitin-proteasome system; and proteasome localization. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STS1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (377287..378246, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit MSL1 Neighboring gene MIND complex subunit DSN1 Neighboring gene Sqt1p Neighboring gene Gat4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DBF8, an essential gene required for efficient chromosome segregation in Saccharomyces cerevisiae. Houman F, et al. Mol Cell Biol, 1994 Sep. PMID 8065366, Free PMC Article
    2. Multicopy STS1 restores both protein transport and ribosomal RNA stability in a new yeast sec23 mutant allele. Liang S, et al. Eur J Cell Biol, 1993 Dec. PMID 7925484
    3. Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1. Breckel CA, et al. Sci Rep, 2024 Jan 24. PMID 38267508, Free PMC Article
    4. Yeast importin-α (Srp1) performs distinct roles in the import of nuclear proteins and in targeting proteasomes to the nucleus. Chen L, et al. J Biol Chem, 2014 Nov 14. PMID 25274630, Free PMC Article
    5. Mutations in STS1 suppress the defect in 3' mRNA processing caused by the rna15-2 mutation in Saccharomyces cerevisiae. Amrani N, et al. Mol Gen Genet, 1996 Oct 16. PMID 8914516

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1.
      Title: Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1.
    2. This study unveils a previously unknown role for Srp1 and Sts1 in cotranslational protein degradation and suggests a novel model whereby Srp1 and Sts1 cooperate to couple proteasomes to ribosome-bound nascent polypeptides.
      Title: Nuclear import factor Srp1 and its associated protein Sts1 couple ribosome-bound nascent polypeptides to proteasomes for cotranslational degradation.
    3. Sts1 plays a key role in targeting proteasomes to the nucleus.
      Title: Sts1 plays a key role in targeting proteasomes to the nucleus.
    4. Sts1 is a new regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.
      Title: Sts1 can overcome the loss of Rad23 and Rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear protein quality control by the ubiquitin-proteasome system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sts1p
    NP_012276.1
    • Karyopherin adaptor required for nuclear translocation of the proteasome; mediates interaction between nuclear import factor Srp1p and the proteasome; nuclear import of the 26S proteasome is coupled to RanGTP-initiated, ubiquitin-independent proteasomal degradation of Sts1p; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; role in ubiquitin-mediated protein degradation; contains a bipartite nuclear localization sequence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      377287..378246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179533.1 → NP_012276.1  TPA: Sts1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LTJ8, C7GJG1, C8ZAR0, D6VVU1, E7KDX7, E7LVV3, E7QG80, P35188, P38637
      UniProtKB/TrEMBL
      G2WGF7, N1P977
      Conserved Domains (1) summary
      pfam08559
      Location:79 → 274
      Cut8; nuclear proteasome tether protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38637.1

    Gene LinkOut

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