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    spx2 SPX/EXS domain-containing protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361154, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spx2
    Official Full Name
    SPX/EXS domain-containing protein
    Primary source
    PomBase:SPCC1827.07c
    Locus tag
    SPOM_SPCC1827.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCP1E11.01c
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    Genomic context

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    See spx2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003421.2 (2388317..2391285, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene RNA-binding protein NIFK Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene aspartate semialdehyde dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ark1/Prk1 family protein kinase Ppk38

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphate uptake restriction, phosphate export, and polyphosphate synthesis contribute synergistically to cellular proliferation and survival. Takado M, et al. J Biol Chem, 2023 Dec. PMID 37949217, Free PMC Article
    2. Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast. Schwer B, et al. mBio, 2022 Feb 22. PMID 35012333, Free PMC Article
    3. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article
    4. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article
    5. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast.
      Title: Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables inositol hexakisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphate ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SPX/EXS domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2388317..2391285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023540.4 → NP_588554.2  SPX/EXS domain-containing protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588554.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74979, Q9UU86
      Conserved Domains (3) summary
      COG5408
      Location:1 → 272
      COG5408; SPX domain-containing protein [Signal transduction mechanisms]
      COG5409
      Location:271 → 641
      COG5409; EXS domain-containing protein [Signal transduction mechanisms]
      cd14475
      Location:2 → 207
      SPX_SYG1_like; SPX domain of the yeast plasma protein Syg1 and related proteins
    Nucleotide Protein
    Heading Accession and Version

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