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    VHR2 Vhr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VHR2
    Official Full Name
    Vhr2p
    Primary source
    SGD:S000000866
    Locus tag
    YER064C
    See related
    AllianceGenome:SGD:S000000866; FungiDB:YER064C; VEuPathDB:YER064C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Involved in regulation of DNA-templated transcription. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VHR2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (282705..284222, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene glycerol-1-phosphatase GPP2 Neighboring gene Tho1p Neighboring gene isocitrate lyase 1 Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae. Kennedy MA, et al. Biochim Biophys Acta, 2001 Jan 26. PMID 11342098
    2. TORC1 ensures membrane trafficking of Tat2 tryptophan permease via a novel transcriptional activator Vhr2 in budding yeast. Daicho K, et al. Cell Signal, 2020 Apr. PMID 31954176
    3. Lsm12 Mediates Deubiquitination of DNA Polymerase η To Help Saccharomyces cerevisiae Resist Oxidative Stress. Yao R, et al. Appl Environ Microbiol, 2019 Jan 1. PMID 30366994, Free PMC Article
    4. The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. Kochan DZ, et al. J Cell Sci, 2021 Aug 1. PMID 34350963, Free PMC Article
    5. Whi3, an S. cerevisiae RNA-binding protein, is a component of stress granules that regulates levels of its target mRNAs. Holmes KJ, et al. PLoS One, 2013. PMID 24386330, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vhr2p
    NP_010986.1
    • Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      282705..284222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178955.1 → NP_010986.1  TPA: Vhr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLW9, P40041
      UniProtKB/TrEMBL
      A6ZR18, B3LS78
      Conserved Domains (1) summary
      pfam04001
      Location:22 → 103
      Vhr1; Transcription factor Vhr1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40041.1

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